Association of UCP2-866 G/A polymorphism with chronic inflammatory diseases

被引：73

作者：

Yu, X.

Wieczorek, S. ^{[2
]}

Franke, A. ^{[3
]}

Yin, H. ^{[4
]}

Pierer, M. ^{[5
]}

Sina, C. ^{[6
]}

Karlsen, T. H. ^{[7
]}

Boberg, K. M. ^{[7
]}

Bergquist, A. ^{[8
]}

Kunz, M. ^{[9
]}

Witte, T. ^{[10
]}

Gross, W. L. ^{[11
]}

Epplen, J. T. ^{[2
]}

Alarcon-Riquelme, M. E. ^{[4
]}

Schreiber, S. ^{[3
,6
]}

Ibrahim, S. M. ^{[1
]}

机构：

[1] Univ Rostock, Immunogenet Grp, Sect Immunogenet, D-18055 Rostock, Germany

[2] Ruhr Univ Bochum, Dept Human Genet, IGSN, Bochum, Germany

[3] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

[4] Uppsala Univ, Dept Gen & Pathol, Uppsala, Sweden

[5] Univ Leipzig, Dept Med 4, Leipzig, Germany

[6] Univ Kiel, Univ Hosp Schleswig Holstein, Dept Gen Internal Med, Kiel, Germany

[7] Univ Hosp, Rikshosp, Dept Med, Oslo, Norway

[8] Karolinska Univ Hosp, Dept Gastroenterol & Hepatol, Stockholm, Sweden

[9] Univ Rostock, Dermatol Clin, Rostock, Germany

[10] Hannover Med Sch, Dept Immunol & Rheumatol, D-3000 Hannover, Germany

[11] Univ Hosp Schleswig Holstein, Dept Rheumatol, Lubeck, Germany

来源：

GENES AND IMMUNITY | 2009年 / 10卷 / 06期

关键词：

mitochondria; chronic inflammatory diseases; uncoupling protein 2; UNCOUPLING PROTEIN-2; COMMON POLYMORPHISM; MULTIPLE-SCLEROSIS; PROMOTER; RISK; MICE;

D O I：

10.1038/gene.2009.29

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We reported earlier that two mitochondrial gene polymorphisms, UCP2 -866 G/A (rs659366) and mtDNA nt13708 G/A (rs28359178), are associated with multiple sclerosis ( MS). Here we aim to investigate whether these functional polymorphisms contribute to other eight chronic inflammatory diseases, including rheumatoid arthritis ( RA), systemic lupus erythematosus (SLE), Wegener' granulomatosis (WG), Churg-Strauss syndrome (CSS), Crohn's disease ( CD), ulcerative colitis (UC), primary sclerosing cholangitis (PSC) and psoriasis. Compared with individual control panels, the UCP2-866 G/A polymorphism was associated with RA and SLE, and the mtDNA nt13708 G/A polymorphism with RA. Compared with combined controls, the UCP2-866 G/A polymorphism was associated with SLE, WG, CD and UC. When all eight disease panels and the original MS panel were combined in a meta-analysis, the UCP2 was associated with chronic inflammatory diseases in terms of either alleles ( odds ratio ( OR) = 0.91, 95% confidence interval ( 95% CI): 0.86-0.96), P = 0.0003) or genotypes ( OR = 0.88, ( 95% CI: 0.82-0.95), P = 0.0008), with the -866A allele associated with a decreased risk to diseases. As the -866A allele increases gene expression, our findings suggest a protective role of the UCP2 protein in chronic inflammatory diseases. Genes and Immunity ( 2009) 10, 601-605; doi:10.1038/gene.2009.29; published online 23 April 2009

引用

页码：601 / 605

页数：5

共 15 条

[1] Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production [J].