Direct association between caspase 3 and α6β1 integrin and its role during anoikis of rat fibroblasts

被引：12

作者：

Rajeswari, J. ^{[1
]}

Pande, Gopal ^{[1
]}

机构：

[1] Ctr Cellular & Mol Biol, Dept Cell Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

CELL BIOLOGY INTERNATIONAL | 2006年 / 30卷 / 12期

关键词：

cell adhesion; apoptosis; integrins and caspases;

D O I：

10.1016/j.cellbi.2006.06.022

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have demonstrated a direct association between alpha 5 beta 1 integrin and caspase 3, both pro- and mature enzyme, in various sub-cellular compartments of rat fibroblasts undergoing anoikis. Integrin associated caspase 3 showed high activity in the plasma membranes, whereas in the cytosol and microsomal fraction it showed little or no activity. Our results suggest a possible role for recycled un-ligated alpha 5 beta 1 integrin molecules between cytosol and plasma membrane, in regulation of caspase-3 activity and induction of cell death in adhesion-deprived cells. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

引用

页码：963 / 969

页数：7

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