Role of iron in cancer development by viruses

被引：6
作者：
Shoja, Zabihollah [1 ]
Chenari, Maryam [2 ]
Jafarpour, Ali [2 ]
Jalilvand, Somayeh [2 ]
机构：
[1] Pasteur Inst Iran, Dept Virol, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Publ Hlth, Dept Virol, Tehran 14155, Iran
来源：
REVIEWS IN MEDICAL VIROLOGY | 2019年 / 29卷 / 04期
关键词：
iron; cancer; viruses; CHRONIC HEPATITIS-C; SARCOMA-ASSOCIATED HERPESVIRUS; INTERLEUKIN-6; GENE-EXPRESSION; CHRONIC LIVER-DISEASE; OXIDATIVE DNA-DAMAGE; KAPOSIS-SARCOMA; HEPATOCELLULAR-CARCINOMA; SERUM IRON; HEME OXYGENASE-1; HEPCIDIN EXPRESSION;
D O I：
10.1002/rmv.2045
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Increased levels of iron in body are attributed to higher cancer risk. Given the fact that 16% of all human cancers are caused by viral infections, iron is suggested to play an important role in carcinogenesis particularly those induced by viral infections. The present study provides an updated summary of the literature and the plausible mechanisms of iron involvement in cancer development by viruses. Our understanding about the interplay between viral infections and iron in different settings particularly cancer development is yet to be improved as it may shed a new light in development of new therapeutic strategies.
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页数：12
相关论文
共 156 条
[1]   Iron absorption and metabolism [J].
Anderson, Gregory J. ;
Frazer, David M. ;
McLaren, Gordon D. .
CURRENT OPINION IN GASTROENTEROLOGY, 2009, 25 (02) :129-135
[2]  
[Anonymous], 2012, GLOBOCAN 2012 ESTIMA
[3]   Estimation of Copper and Iron Burden in Biological Samples of Various Stages of Hepatitis C and Liver Cirrhosis Patients [J].
Arain, Salma Aslam ;
Kazi, Tasneem G. ;
Afridi, Hassan Imran ;
Talpur, Farah Naz ;
Mughal, Moina Akhtar ;
Shah, Faheem ;
Arain, Sadaf Sadia ;
Panhwar, Abdul Haleem .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2014, 160 (02) :197-205
[4]   Modulation of hepatitis C virus replication by iron and hepcidin in Huh7 hepatocytes [J].
Bartolomei, Giody ;
Cevik, Recep Emrah ;
Marcello, Alessandro .
JOURNAL OF GENERAL VIROLOGY, 2011, 92 :2072-2081
[5]   Epidemiological and nonclinical studies investigating effects of iron in carcinogenesis-A critical review [J].
Beguin, Yves ;
Aapro, Matti ;
Ludwig, Heinz ;
Mizzen, Lee ;
Osterborg, Anders .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2014, 89 (01) :1-15
[6]   CHANGES IN SERUM IRON LEVELS DUE TO INFECTION WITH HEPATITIS-B VIRUS [J].
BLUMBERG, BS ;
LUSTBADER, ED ;
WHITFORD, PL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (05) :3222-3224
[7]   Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease [J].
Bogdan, Alexander R. ;
Miyazawa, Masaki ;
Hashimoto, Kazunori ;
Tsuji, Yoshiaki .
TRENDS IN BIOCHEMICAL SCIENCES, 2016, 41 (03) :274-286
[8]   The Heme Metabolite Carbon Monoxide Facilitates KSHV Infection by Inhibiting TLR4 Signaling in Endothelial Cells [J].
Botto, Sara ;
Gustin, Jean K. ;
Moses, Ashlee V. .
FRONTIERS IN MICROBIOLOGY, 2017, 8
[9]   Kaposi Sarcoma Herpesvirus Induces HO-1 during De Novo Infection of Endothelial Cells via Viral miRNA-Dependent and -Independent Mechanisms [J].
Botto, Sara ;
Totonchy, Jennifer E. ;
Gustin, Jean K. ;
Moses, Ashlee V. .
MBIO, 2015, 6 (03)
[10]   Overexpression of cellular iron import proteins is associated with malignant progression of Esophageal adenocarcinoma [J].
Boult, Jessica ;
Roberts, Keith ;
Brookes, Matthew J. ;
Hughes, Sharon ;
Bury, Jonathan P. ;
Cross, Simon S. ;
Anderson, Gregory J. ;
Spychal, Robert ;
Lqbal, Tariq ;
Tselepis, Chris .
CLINICAL CANCER RESEARCH, 2008, 14 (02) :379-387
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