Quantizing single-molecule surface-enhanced Raman scattering with DNA origami metamolecules

被引：167

作者：

Fang, Weina ^{[1
,2
,3
]}

Jia, Sisi ^{[3
]}

Chao, Jie ^{[4
,5
]}

Wang, Liqian ^{[3
]}

Duan, Xiaoyang ^{[6
,7
]}

Liu, Huajie ^{[3
,8
]}

Li, Qian ^{[1
,2
]}

Zuo, Xiaolei ^{[1
,2
]}

Wang, Lihua ^{[3
]}

Wang, Lianhui ^{[4
,5
,9
]}

Liu, Na ^{[6
,7
]}

Fan, Chunhai ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China

[4] Nanjing Univ Posts & Telecommun, IAM, KLOEID, 9 Wenyuan Rd, Nanjing 210046, Jiangsu, Peoples R China

[5] Nanjing Univ Posts & Telecommun, Sch Mat Sci & Engn, 9 Wenyuan Rd, Nanjing 210046, Jiangsu, Peoples R China

[6] Max Planck Inst Intelligent Syst, Heisenbergstr 3, D-70569 Stuttgart, Germany

[7] Heidelberg Univ, Kirchhoff Inst Phys, Neuenheimer Feld 227, D-69120 Heidelberg, Germany

[8] Tongji Univ, Sch Chem Sci & Engn, Shanghai 200092, Peoples R China

[9] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 500 Dongchuan Rd, Shanghai 200241, Peoples R China

来源：

SCIENCE ADVANCES | 2019年 / 5卷 / 09期

基金：

美国国家科学基金会; 国家重点研发计划;

关键词：

NANOPARTICLES; NANOANTENNAS; DIMERS; LIGHT;

D O I：

10.1126/sciadv.aau4506

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tailored metal nanoclusters have been actively developed to manipulate light at the subwavelength scale for nanophotonic applications. Nevertheless, precise arrangement of molecules in a hot spot with fixed numbers and positions remains challenging. Here, we show that DNA origami metamolecules with Fano resonances (DMFR) can precisely localize single dye molecules and produce quantified surface-enhanced Raman scattering (SERS) responses. To enable tailored plasmonic permutations, we develop a general and programmable method for anchoring a set of large gold nanoparticles (L-AuNPs) on prescribed n-tuple docking sites of super-origami DNA frameworks. A tetrameric nanocluster with four spatially organized 80-nm L-AuNPs exhibits peak-and-dip Fano characteristics. The drastic enhancement at the wavelength of the Fano minimum allows the collection of prominent SERS spectrum for even a single dye molecule. We expect that DMFR provides physical insights into single-molecule SERS and opens new opportunities for developing plasmonic nanodevices for ultrasensitive sensing, nanocircuits, and nanophotonic lasers.

引用

页数：8

共 40 条

[1] Fluorescence Enhancement at Docking Sites of DNA-Directed Self-Assembled Nanoantennas [J].