Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation

被引：10

作者：

Marcela Chalela, Claudia ^{[1
]}

Maria Pena, Angela ^{[1
,2
]}

Maria Roa, Angela ^{[1
]}

Reyes, David L. ^{[1
]}

Paola Rueda, Jennifer ^{[1
]}

Antonio Salazar, Luis ^{[1
,2
]}

Rosales, Manuel ^{[2
]}

David Gomez, Edgar ^{[1
,3
]}

Augusto Bernal, Edgar ^{[4
]}

Sossa Melo, Claudia Lucia ^{[1
,2
]}

机构：

[1] Univ Autonoma Bucaramanga, Fac Hlth Sci, Bucaramanga, Santander, Colombia

[2] Clin FOSCAL, Hematopoiet & Stem Cell Transplantat Unit, Floridablanca, Santander, Colombia

[3] Clin FOSCAL, Dept Internal Med, Floridablanca, Santander, Colombia

[4] Clin FOSCAL, Dept Infect Dis, Floridablanca, Santander, Colombia

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2021年 / 54卷

关键词：

Stem cell transplantation; Chagas disease; Trypanosoma cruzi; UNITED-STATES; PATIENT;

D O I：

10.1590/0037-8682-0143-2020

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.

引用

页码：1 / 4

页数：4

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