Recent developments in natural product-based drug discovery for tuberculosis

被引：30

作者：

Dong, Maryline ^{[1
]}

Pfeiffer, Bernhard ^{[1
]}

Altmann, Karl-Heinz ^{[1
]}

机构：

[1] ETH, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, Vladimir Prelog Weg 4,HCI H 405, CH-8093 Zurich, Switzerland

来源：

DRUG DISCOVERY TODAY | 2017年 / 22卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

MYCOBACTERIUM-TUBERCULOSIS; DIAZAQUINOMYCIN-A; TIACUMICIN B; LIPIARMYCIN; INHA; ANTIBIOTICS; PYRIDOMYCIN; TARGET; CAPRAZAMYCINS; ANALOGS;

D O I：

10.1016/j.drudis.2016.11.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Natural products (NPs) have been at the origin of several established drugs against tuberculosis (TB). Although the current clinical TB pipeline does not feature any candidates derived from new NP scaffolds, numerous novel NPs or NP analogs have been discovered in the recent past with promising activity against Mycobacterium tuberculosis (Mtb). This includes newly discovered structures as well as known NP classes that had not been previously recognized to be active against Mtb. These compounds could help to replenish the dry clinical TB pipeline and, thus, contribute to improvements in the treatment of a devastating disease.

引用

收藏

页码：585 / 591

页数：7

相关论文

共 60 条

[1]

Ahmad Z, 2011, PROG RESPIR RES, V40, P2

[2]

[Anonymous], 2015, Global Tuberculosis Report

[3] Fidaxomicin Is an Inhibitor of the Initiation of Bacterial RNA Synthesis [J].

Artsimovitch, Irina ;

Seddon, Jaime ;

Sears, Pamela .

CLINICAL INFECTIOUS DISEASES, 2012, 55 :S127-S131

[4] INHA, A GENE ENCODING A TARGET FOR ISONIAZID AND ETHIONAMIDE IN MYCOBACTERIUM-TUBERCULOSIS [J].

BANERJEE, A ;

DUBNAU, E ;

QUEMARD, A ;

BALASUBRAMANIAN, V ;

UM, KS ;

WILSON, T ;

COLLINS, D ;

DELISLE, G ;

JACOBS, WR .

SCIENCE, 1994, 263 (5144) :227-230

[5] Total synthesis of desoxycyclomarin C and the cyclomarazines A and B [J].

Barbie, Philipp ;

Kazmaier, Uli .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 14 (25) :6055-6064

[6]

Bedeschi A, 2014, NAT PROD COMMUN, V9, P237

[7] Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action [J].

Buerstner, Nathalie ;

Roggo, Silvio ;

Ostermann, Nils ;

Blank, Jutta ;

Delmas, Cecile ;

Freuler, Felix ;

Gerhartz, Bernd ;

Hinniger, Alexandra ;

Hoepfner, Dominic ;

Liechty, Brigitta ;

Mihalic, Manuel ;

Murphy, Jason ;

Pistorius, Dominik ;

Rottmann, Matthias ;

Thomas, Jason R. ;

Schirle, Markus ;

Schmitt, Esther K. .

CHEMBIOCHEM, 2015, 16 (17) :2433-2436

[8] Natural product growth inhibitors of Mycobacterium tuberculosis [J].

Copp, Brent R. ;

Pearce, A. Norrie .

NATURAL PRODUCT REPORTS, 2007, 24 (02) :278-297

[9] LIPIARMYCIN, A NEW ANTIBIOTIC FROM ACTINOPLANES .2. ISOLATION, CHEMICAL, BIOLOGICAL AND BIOCHEMICAL CHARACTERIZATION [J].

CORONELLI, C ;

WHITE, RJ ;

LANCINI, GC ;

PARENTI, F .

JOURNAL OF ANTIBIOTICS, 1975, 28 (04) :253-259

[10] The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo [J].

Gao, Wei ;

Kim, Jin-Yong ;

Anderson, Jeffrey R. ;

Akopian, Tatos ;

Hong, Seungpyo ;

Jin, Ying-Yu ;

Kandror, Olga ;

Kim, Jong-Woo ;

Lee, In-Ae ;

Lee, Sun-Young ;

McAlpine, James B. ;

Mulugeta, Surafel ;

Sunoqrot, Suhair ;

Wang, Yuehong ;

Yang, Seung-Hwan ;

Yoon, Tae-Mi ;

Goldberg, Alfred L. ;

Pauli, Guido F. ;

Suh, Joo-Won ;

Franzblau, Scott G. ;

Cho, Sanghyun .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (02) :880-889

← 1 2 3 4 5 6 →