The role of osteocytes and bone microstructure in preventing osteoporotic fractures

被引：39
作者：
Hazenberg, Jan G.
Taylor, David
Lee, T. Clive
机构：
[1] Royal Coll Surgeons Ireland, Dept Anat, Dublin 2, Ireland
[2] Univ Dublin Trinity Coll, Trinity Ctr Bioengn, Dublin 2, Ireland
来源：
OSTEOPOROSIS INTERNATIONAL | 2007年 / 18卷 / 01期
关键词：
bone adaptation; microdamage; osteocytes; osteoporotic fracture; RANKL;
D O I：
10.1007/s00198-006-0222-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The skeleton alters its geometry following trauma, the introduction of artificial defects and of fatigue-induced microcracks. The precise mechanism by which the skeleton adapts remains unclear. Microcracks might directly affect the cell by damaging the osteocyte cell network or causing apoptosis. Bone microstructure may play an important role in these processes by diverting and arresting propagating microcracks and so prevent fracture failure. This paper discusses the effects of microstructure on propagating cracks, how microdamage may act as a stimulus for bone adaptation and its potential effects on bone biochemistry.
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页码：1 / 8
页数：8
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