A confederacy of kinases: Cdk2 and Cdk4 conspire to control embryonic cell proliferation

被引：7
|
作者：
Hinds, PW [1 ]
机构：
[1] Tufts New England Med Ctr, Dept Radiat Oncol, Mol Oncol Res Inst, Boston, MA 02115 USA
来源：
MOLECULAR CELL | 2006年 / 22卷 / 04期
关键词：
D O I：
10.1016/j.molcel.2006.05.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mouse embryo is surprisingly resistant to loss of individual cyclins or cyclin-dependent kinases. In a recent issue of Developmental Cell, Berthet et al. (2006) describe collaboration of Cdk2 and Cdk4 in embryogenesis that is revealed only upon their simultaneous loss, resulting in inappropriate activation of the retinoblastoma protein and embryonic lethality.
引用
收藏
页码：432 / 433
页数：2
相关论文
共 50 条
  • [31] Cyclin-dependent kinase (cdk) inhibitors/cdk4/cdk2 complexes in early stages of mouse mammary preneoplasia
    Said, TK
    Moraes, RCB
    Singh, U
    Kittrell, FS
    Medina, D
    CELL GROWTH & DIFFERENTIATION, 2001, 12 (06): : 285 - 295
  • [32] Activation of cdk4 and cdk2 during rat liver regeneration is associated with intranuclear rearrangements of cyclin-cdk complexes
    Jaumot, M
    Estanyol, JM
    Serratosa, J
    Agell, N
    Bachs, O
    HEPATOLOGY, 1999, 29 (02) : 385 - 395
  • [33] CDK2、CDK4基因与自体移植静脉内膜增殖的关系
    亓明
    王新文
    罗英伟
    秦岭峰
    马文锋
    张强
    辛世杰
    段志泉
    大连医科大学学报, 2012, 34 (02) : 134 - 137+149
  • [34] An insight into the inhibitory selectivity of 4-(Pyrazol-4-yl)-pyrimidines to CDK4 over CDK2
    Dong, Keke
    Yang, Xueyu
    Zhao, Tengteng
    Zhu, Xiaolei
    MOLECULAR SIMULATION, 2017, 43 (08) : 599 - 609
  • [35] Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells
    Kimberley J Sweeney
    Boris Sarcevic
    Robert L Sutherland
    Elizabeth A Musgrove
    Oncogene, 1997, 14 : 1329 - 1340
  • [36] Molecular docking analysis of piperine with CDK2, CDK4, Cyclin D and Cyclin T proteins
    Rekha, Umaphathy Vidhya
    Anita, M.
    Jayamathi, Govindaraj
    Sadhana, K.
    Deepa, Subramanian
    Hussain, Sajid
    Bhuvaneswari, J.
    Ramya, V
    Selvaraj, Jayaraman
    BIOINFORMATION, 2020, 16 (05) : 359 - 361
  • [37] Comparative analysis of the surface interaction properties of the binding sites of CDK2, CDK4, and ERK2
    Kelly, Matthew D.
    Mancera, Ricardo L.
    CHEMMEDCHEM, 2006, 1 (03) : 366 - 375
  • [38] Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells
    Sweeney, KJ
    Sarcevic, B
    Sutherland, RL
    Musgrove, EA
    ONCOGENE, 1997, 14 (11) : 1329 - 1340
  • [39] CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point
    Bisteau, Xavier
    Paternot, Sabine
    Colleoni, Bianca
    Ecker, Karin
    Coulonval, Katia
    De Groote, Philippe
    Declercq, Wim
    Hengst, Ludger
    Roger, Pierre P.
    PLOS GENETICS, 2013, 9 (05):
  • [40] CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis-Competent Conformations, Offering Drug Targets
    Zhang, Wengang
    Liu, Yonglan
    Jang, Hyunbum
    Nussinov, Ruth
    JACS AU, 2024, 4 (05): : 1911 - 1927
12345