A confederacy of kinases: Cdk2 and Cdk4 conspire to control embryonic cell proliferation

被引：7
|
作者：
Hinds, PW [1 ]
机构：
[1] Tufts New England Med Ctr, Dept Radiat Oncol, Mol Oncol Res Inst, Boston, MA 02115 USA
来源：
MOLECULAR CELL | 2006年 / 22卷 / 04期
关键词：
D O I：
10.1016/j.molcel.2006.05.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mouse embryo is surprisingly resistant to loss of individual cyclins or cyclin-dependent kinases. In a recent issue of Developmental Cell, Berthet et al. (2006) describe collaboration of Cdk2 and Cdk4 in embryogenesis that is revealed only upon their simultaneous loss, resulting in inappropriate activation of the retinoblastoma protein and embryonic lethality.
引用
收藏
页码：432 / 433
页数：2
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