Auditory tracts identified with combined fMRI and diffusion tractography

被引:55
作者
Javad, Faiza [1 ]
Warren, Jason D. [2 ]
Micallef, Caroline [1 ,3 ]
Thornton, John S. [1 ,3 ]
Golay, Xavier [1 ,3 ]
Yousry, Tarek [1 ,3 ]
Mancini, Laura [1 ,3 ]
机构
[1] UCL, UCL Inst Neurol, Dept Brain Repair & Rehabil, Neuroradiol Acad Unit, London WC1N 3BG, England
[2] UCL, UCL Inst Neurol, Dementia Res Ctr, London WC1N 3BG, England
[3] UCLH NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Lysholm Dept Neuroradiol, London WC1N 3BG, England
基金
英国惠康基金;
关键词
Auditory tracts; Auditory radiation; fMRI; DTI; Tractography; SUPERIOR TEMPORAL REGION; FUNCTIONAL MRI; CORTICAL AREAS; HUMAN BRAIN; CORTEX; MOTOR; ORGANIZATION; CAT; CONNECTIONS; TOPOGRAPHY;
D O I
10.1016/j.neuroimage.2013.09.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The auditory tracts in the human brain connect the inferior colliculus (IC) and medial geniculate body (MGB) to various components of the auditory cortex (AC). While in non-human primates and in humans, the auditory system is differentiated in core, belt and parabelt areas, the correspondence between these areas and anatomical landmarks on the human superior temporal gyri is not straightforward, and at present not completely understood. However it is not controversial that there is a hierarchical organization of auditory stimuli processing in the auditory system. The aims of this study were to demonstrate that it is possible to non-invasively and robustly identify auditory projections between the auditory thalamus/brainstem and different functional levels of auditory analysis in the cortex of human subjects in vivo combining functional magnetic resonance imaging (fMRI) with diffusion MRI, and to investigate the possibility of differentiating between different components of the auditory pathways (e.g. projections to areas responsible for sound, pitch and melody processing). We hypothesized that the major limitation in the identification of the auditory pathways is the known problem of crossing fibres and addressed this issue acquiring DTI with b-values higher than commonly used and adopting a multi-fibre ball-and-stick analysis model combined with probabilistic tractography. Fourteen healthy subjects were studied. Auditory areas were localized functionally using an established hierarchical pitch processing fMRI paradigm. Together fMRI and diffusion MRI allowed the successful identification of tracts connecting IC with AC in 64 to 86% of hemispheres and left sound areas with homologous areas in the right hemisphere in 86% of hemispheres. The identified tracts corresponded closely with a three-dimensional stereotaxic atlas based on postmortem data. The findings have both neuroscientific and clinical implications for delineation of the human auditory system in vivo. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:562 / 574
页数:13
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