The Liver in Sickle Cell Disease

被引：45

作者：

Theocharidou, Eleni ^{[1
]}

Suddle, Abid R. ^{[1
]}

机构：

[1] Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, Denmark Hill, London SE5 9RS, England

来源：

CLINICS IN LIVER DISEASE | 2019年 / 23卷 / 02期

关键词：

Sickle cell hepatopathy; Intrahepatic cholestasis; Sickle hepatic crisis; Iron overload; Viral hepatitis; Cholelithiasis; CHRONIC HEPATITIS-C; INTRAHEPATIC CHOLESTASIS; LAPAROSCOPIC CHOLECYSTECTOMY; EXCHANGE-TRANSFUSION; IRON OVERLOAD; PATIENT; TRANSPLANTATION; ANEMIA; CHILDREN; THALASSEMIA;

D O I：

10.1016/j.cld.2018.12.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Patients with sickle cell disease can develop liver disease as a result of intrahepatic sickling of erythrocytes, viral hepatitis and iron overload secondary to multiple blood transfusions, and gallstone disease as a result of chronic hemolysis. The spectrum of clinical liver disease is wide and often multifactorial. Some patients develop cirrhosis that may progress to end-stage liver failure. Limited evidence exists for medical treatments. Exchange blood transfusions may improve outcomes in the acute liver syndromes. Liver transplantation may be an option for chronic liver disease. The role for prophylactic cholecystectomy in preventing complications of gallstone disease is controversial.

引用

页码：177 / +

页数：14

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