Wolbachia Invades Anopheles stephensi Populations and Induces Refractoriness to Plasmodium Infection

被引：346
作者：
Bian, Guowu [1 ,2 ]
Joshi, Deepak [1 ]
Dong, Yuemei [3 ]
Lu, Peng [1 ]
Zhou, Guoli [1 ]
Pan, Xiaoling [1 ]
Xu, Yao [1 ]
Dimopoulos, George [3 ]
Xi, Zhiyong [1 ,4 ]
机构：
[1] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
[2] Sun Yat Sen Univ, Minist Educ, Key Lab Trop Dis Control, Dept Parasitol,Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China
[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA
[4] Sun Yat Sen Univ Michigan State Univ Joint Ctr Ve, Guangzhou 510080, Guangdong, Peoples R China
来源：
SCIENCE | 2013年 / 340卷 / 6133期
关键词：
AEDES-ALBOPICTUS; DENGUE VIRUS; MOSQUITO; ESTABLISHMENT; SYMBIONT; MALARIA;
D O I：
10.1126/science.1236192
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Wolbachia is a maternally transmitted symbiotic bacterium of insects that has been proposed as a potential agent for the control of insect-transmitted diseases. One of the major limitations preventing the development of Wolbachia for malaria control has been the inability to establish inherited infections of Wolbachia in anopheline mosquitoes. Here, we report the establishment of a stable Wolbachia infection in an important malaria vector, Anopheles stephensi. In A. stephensi, Wolbachia strain wAlbB displays both perfect maternal transmission and the ability to induce high levels of cytoplasmic incompatibility. Seeding of naturally uninfected A. stephensi populations with infected females repeatedly resulted in Wolbachia invasion of laboratory mosquito populations. Furthermore, wAlbB conferred resistance in the mosquito to the human malaria parasite Plasmodium falciparum.
引用
收藏
页码：748 / 751
页数：4
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