Galacto-oligosaccharides Derived from Lactulose Exert a Selective Stimulation on the Growth of Bifidobacterium animalis in the Large Intestine of Growing Rats

被引：54

作者：

Carmen Marin-Manzano, M. ^{[1
]}

Abecia, Leticia ^{[1
]}

Hernandez-Hernandez, Oswaldo ^{[2
]}

Sanz, M. Luz ^{[2
]}

Montilla, Antonia ^{[3
]}

Olano, Agustin ^{[3
]}

Rubio, Luis A. ^{[1
]}

Javier Moreno, F. ^{[3
]}

Clemente, Alfonso ^{[1
]}

机构：

[1] CSIC, Estn Expt Zaidin, E-18008 Granada, Spain

[2] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain

[3] Univ Autonoma Madrid, Inst Invest Ciencias Alimentac CIAL, CSIC UAM, E-28049 Madrid, Spain

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2013年 / 61卷 / 31期

关键词：

bifidobacteria; Bifidobacterium animalis; galacto-cligosaccharides; gut microbiota; lactulose; prebiotic; IN-VITRO FERMENTATION; 16S RIBOSOMAL-RNA; DOUBLE-BLIND; FECAL MICROBIOTA; HEALTHY HUMANS; PCR; MICROFLORA; PREBIOTICS; SUPPLEMENTATION; PROBIOTICS;

D O I：

10.1021/jf402218z

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

There is increasing interest in identifying novel dietary nondigestible carbohydrates capable of modulating the composition and/or metabolic activities of the gut microbiota. This work assessed the differential modulatory influence of novel galacto-oligosaccharides derived from lactulose (GOS-Lu) in comparison with commercial galacto-oligosaccharides derived from lactose (GOS-La) in gut microbiota of growing rats (5 weeks old). Rats were fed either a control diet or diets containing 1% (w/w) of GOS-Lu or GOS-La, and cecal and colonic contents were collected after 14 days of treatment. Compared to controls, GOS-Lu had significantly more bifidobacteria within the large intestine, showing a significant and selective increase of Bifidobacterium animalis in the cecum and colon; however, no significant differences in the number of bifidobacteria among GOSLu and GOS-La groups were observed. Both types of GOS significantly increased the number of the Eubacterium rectale/Clostridium coccoides group. These findings support a prebiotic role of galactosyl-fructoses in functional foods.

引用

页码：7560 / 7567

页数：8

共 38 条

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