Antinociceptive effects of A1 and A2 type botulinum toxins on carrageenan-induced hyperalgesia in rat

被引：10

作者：

Shin, Min-Chul ^{[1
]}

Yukihira, Takashi ^{[1
,2
]}

Ito, Yushi ^{[1
]}

Akaike, Norio ^{[1
]}

机构：

[1] Kumamoto Hlth Sci Univ, Res Div Life Sci, Kumamoto 8615598, Japan

[2] Teikyo Univ, Fac Fukuoka Med Technol, Dept Phys Therapy, Fukuoka 8368505, Japan

来源：

TOXICON | 2013年 / 64卷

关键词：

A2NTX; A1LL; Carrageenan; c-Fos; Pain; INFRAORBITAL NERVE CONSTRICTION; NEUROPATHIC PAIN; NEUROTOXINS; MODEL; NEURONS; EXPRESSION; INJECTIONS; DECREASES; MECHANISM; PROTEINS;

D O I：

10.1016/j.toxicon.2012.12.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We performed a study on the antinociceptive effects of A1 and A2 type (A1LL and A2NTX, respectively) botulinum toxin on carrageenan-induced hyperalgesia in the rat. Both A1LL and A2NTX had antinociceptive effects in the carrageenan-induced inflammatory pain model, reducing the mechanical and thermal hyperalgesia. A2NTX also reduced the increase in c-fos immunoreactivity in L4-L5 spinal segments induced by carrageenan, suggesting that A2NTX inhibits the activation of spinal nociceptive afferent fibers that project to the CNS. Our results indicate that A2NTX may offer a new therapeutic tool to treat inflammatory pain. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：12 / 19

页数：8

共 50 条

[21] Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia
Osborne, MG
Coderre, TJ
BRITISH JOURNAL OF PHARMACOLOGY, 1999, 126 (08) : 1840 - 1846
[22] EFFECTS OF PROSTAGLANDIN ANALOGS ON RAT CARRAGEENAN-INDUCED PAW EDEMA
FORDHUTCHINSON, AW
MACINTYRE, DE
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1978, 30 (08) : 527 - 528
[23] EFFECTS OF CHLOMIPRAMINE AND FLUOXETINE ON SUBCUTANEOUS CARRAGEENAN-INDUCED INFLAMMATION IN THE RAT
BIANCHI, M
ROSSONI, G
SACERDOTE, P
PANERAI, AE
BERTI, F
INFLAMMATION RESEARCH, 1995, 44 (11) : 466 - 469
[24] Botulinum toxins subtypes A1 and A2 were transported via different pathways to the contralateral side
Torii, Y.
Akaike, N.
Harakawa, T.
Goto, Y.
Nakahira, S.
Kozaki, S.
Kaji, R.
Ginnaga, A.
TOXICON, 2013, 68 : 100 - 100
[25] PERIPHERAL ADENOSINE A2A RECEPTORS ARE INVOLVED IN CARRAGEENAN-INDUCED MECHANICAL HYPERALGESIA IN MICE
Li, L.
Hao, J. X.
Fredholm, B. B.
Schulte, G.
Wiesenfeld-Hallin, Z.
Xu, X. J.
NEUROSCIENCE, 2010, 170 (03) : 923 - 928
[26] Effects of selective inhibitors of neuronal nitric oxide synthase on carrageenan-induced mechanical and thermal hyperalgesia
Handy, RLC
Moore, PK
NEUROPHARMACOLOGY, 1998, 37 (01) : 37 - 43
[27] THE EFFECTS OF THE CLINICALLY TESTED NMDA RECEPTOR ANTAGONIST MEMANTINE ON CARRAGEENAN-INDUCED THERMAL HYPERALGESIA IN RATS
EISENBERG, E
LACROSS, S
STRASSMAN, AM
EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 255 (1-3) : 123 - 129
[28] Botulinum toxin type A inhibits hyperalgesia in the rat masseter muscle in a carrageenan model of myofascial pain
Neves, Ilana Dantas
Pinho, Pedro Paulo Pereira
Casais-e-Silva, Luciana Lyra
Aguiar, Marcio Cajazeira
ARCHIVES OF ORAL BIOLOGY, 2025, 173
[29] Differences in immunological responses of polyclonal botulinum A1 and A2 antitoxin against A1 and A2 toxin
Torii, Yasushi
Shinmura, Miho
Kohda, Tomoko
Kozaki, Shunji
Takahashi, Motohide
Ginnaga, Akihiro
TOXICON, 2013, 73 : 9 - 16
[30] Thrombolytic Effects in vivo of Nattokinase in a Carrageenan-Induced Rat Model of Thrombosis
Xu, Jianping
Du, Ming
Yang, Xiulin
Chen, Qingquan
Chen, Hong
Lin, Dong-Hong
ACTA HAEMATOLOGICA, 2014, 132 (02) : 247 - 253

← 1 2 3 4 5 →