Antinociceptive effects of A1 and A2 type botulinum toxins on carrageenan-induced hyperalgesia in rat

被引：10
|
作者：
Shin, Min-Chul [1 ]
Yukihira, Takashi [1 ,2 ]
Ito, Yushi [1 ]
Akaike, Norio [1 ]
机构：
[1] Kumamoto Hlth Sci Univ, Res Div Life Sci, Kumamoto 8615598, Japan
[2] Teikyo Univ, Fac Fukuoka Med Technol, Dept Phys Therapy, Fukuoka 8368505, Japan
来源：
TOXICON | 2013年 / 64卷
关键词：
A2NTX; A1LL; Carrageenan; c-Fos; Pain; INFRAORBITAL NERVE CONSTRICTION; NEUROPATHIC PAIN; NEUROTOXINS; MODEL; NEURONS; EXPRESSION; INJECTIONS; DECREASES; MECHANISM; PROTEINS;
D O I：
10.1016/j.toxicon.2012.12.011
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We performed a study on the antinociceptive effects of A1 and A2 type (A1LL and A2NTX, respectively) botulinum toxin on carrageenan-induced hyperalgesia in the rat. Both A1LL and A2NTX had antinociceptive effects in the carrageenan-induced inflammatory pain model, reducing the mechanical and thermal hyperalgesia. A2NTX also reduced the increase in c-fos immunoreactivity in L4-L5 spinal segments induced by carrageenan, suggesting that A2NTX inhibits the activation of spinal nociceptive afferent fibers that project to the CNS. Our results indicate that A2NTX may offer a new therapeutic tool to treat inflammatory pain. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：12 / 19
页数：8
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