Highly regioselective ring-opening of aziridines with arenesulfinates on water: a facile access to β-amino/vinyl sulfones

被引：25

作者：

Chawla, Ruchi ^{[1
]}

Singh, Atul K. ^{[1
]}

Yadav, Lal Dhar S. ^{[1
]}

机构：

[1] Univ Allahabad, Dept Chem, Green Synth Lab, Allahabad 211002, Uttar Pradesh, India

来源：

TETRAHEDRON | 2013年 / 69卷 / 06期

关键词：

Aziridines; Sodium sulfinates; beta-Amino sulfones; Vinyl sulfones; Green methodology; HIV PROTEASE INHIBITORS; AZA-MICHAEL ADDITION; ALPHA-AMINO-ACIDS; VINYL SULFONES; HYDROXY SULFONES; STEREOSELECTIVE-SYNTHESIS; PIPERIDINE-DERIVATIVES; ASYMMETRIC-SYNTHESIS; ANTHRANILIC ACIDS; ALKENYL SULFONES;

D O I：

10.1016/j.tet.2012.12.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a LiBr catalyzed efficient synthesis of beta-amino sulfones from readily available aziridines and sodium sulfinates in good to excellent yields. The synthetic potential of beta-amino sulfones has also been demonstrated by their facile conversion to the corresponding vinyl sulfones. The use of water as reaction media, atom-economy and isolation of products by simple filtration in the case of solid beta-amino sulfones are certain green virtues of the synthetic protocol. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1720 / 1724

页数：5

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