Signaling the mitochondrial unfolded protein response

被引:281
作者
Pellegrino, Mark W. [1 ]
Nargund, Amrita M. [1 ]
Haynes, Cole M. [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2013年 / 1833卷 / 02期
关键词
Mitochondria; UPR; Molecular chaperones; Proteases; Signaling; Protein homeostasis; HEAT-SHOCK RESPONSE; ENDOPLASMIC-RETICULUM; TRANSCRIPTION FACTORS; GENE-EXPRESSION; QUALITY-CONTROL; OXIDATIVE-PHOSPHORYLATION; SPASTIC PARAPLEGIA; YEAST MITOCHONDRIA; PRECURSOR PROTEINS; DNA MUTATIONS;
D O I
10.1016/j.bbamcr.2012.02.019
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondria are compartmentalized organelles essential for numerous cellular functions including ATP generation, iron-sulfur cluster biogenesis, nucleotide and amino acid metabolism as well as apoptosis. To promote biogenesis and proper function, mitochondria have a dedicated repertoire of molecular chaperones to facilitate protein folding and quality control proteases to degrade those proteins that fail to fold correctly. Mitochondrial protein folding is challenged by the complex organelle architecture, the deleterious effects of electron transport chain-generated reactive oxygen species and the mitochondrial genome's susceptibility to acquiring mutations. In response to the accumulation of unfolded or misfolded proteins beyond the organelle's chaperone capacity, cells mount a mitochondrial unfolded protein response (UPRmt). The UPRmt is a mitochondria-to-nuclear signal transduction pathway resulting in the induction of mitochondrial protective genes including mitochondrial molecular chaperones and proteases to re-establish protein homeostasis within the mitochondrial protein-folding environment. Here, we review the current understanding of UPRmt signal transduction and the impact of the UPRmt on diseased cells. This article is part of a Special Issue entitled: Protein Import and Quality Control in Mitochondria and Plastids. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:410 / 416
页数:7
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