Aromatase and regulation of bone remodeling

被引：11

作者：

Ribot, C ^{[1
]}

Trémollieres, F ^{[1
]}

Pouillés, JM ^{[1
]}

机构：

[1] Hop Paule Viguier, UF Menopause & Malad Osseuse Metab, F-31403 Toulouse 4, France

来源：

JOINT BONE SPINE | 2006年 / 73卷 / 01期

关键词：

estrogens; bone remodeling; aromatase; osteoporosis;

D O I：

10.1016/j.jbspin.2005.02.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Estrogens play a key role in regulating bone mineralization. Bone tissue expresses the enzymes that metabolize estrogens, as well as the a and P receptors that mediate responses to estrogens. After the menopause, estrogen secretion by the ovaries is promptly replaced by production within tissues, which occurs chiefly via aromatization of adrenal steroids. Therefore, aromatase activity is a major determinant of estrogen activity in postmenopausal women. Studies are beginning to shed light on the mechanisms by which aromatase activity influences bone remodeling. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：37 / 42

页数：6

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