Parkinson's disease: an update on pathogenesis and treatment

被引：28

作者：

Foltynie, Tom ^{[1
,2
]}

Kahan, Joshua ^{[2
]}

机构：

[1] Natl Hosp Neurol & Neurosurg, Box 146,Queen Sq, London WC1N 3BG, England

[2] UCL Inst Neurol, Sobell Dept Motor Neurosci, London WC1N 3BG, England

来源：

JOURNAL OF NEUROLOGY | 2013年 / 260卷 / 05期

关键词：

Parkinson's disease; Pathogenesis; Treatment; Update; ALPHA-SYNUCLEIN; NEUROTROPHIC FACTOR; SUBSTANTIA-NIGRA; CONTROLLED-TRIAL; DOPAMINERGIC-NEURONS; RODENT MODELS; GENE-THERAPY; COMPLEX-I; GLUCOCEREBROSIDASE; BRAIN;

D O I：

10.1007/s00415-013-6915-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Parkinson's disease research field is a rapidly moving one, as many of the relevant processes underlying PD neurodegeneration are being deciphered, enabling novel approaches to treatment to be assessed both in the laboratory and in the clinic. This review aims to highlight the most relevant updates in the PD field, with emphasis on research that may help lead towards an improvement in the treatment of this condition.

引用

页码：1433 / 1440

页数：8

共 76 条

[1] Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease [J].

Abramov, Andrey Yurevich ;

Gegg, Matthew ;

Grunewald, Anne ;

Wood, Nicholas William ;

Klein, Christine ;

Schapira, Anthony Henry Vernon .

PLOS ONE, 2011, 6 (10)

[2] Creatine and Its Potential Therapeutic Value for Targeting Cellular Energy Impairment in Neurodegenerative Diseases [J].

Adhihetty, Peter J. ;

Beal, M. Flint .

NEUROMOLECULAR MEDICINE, 2008, 10 (04) :275-290

[3] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[4] Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Schapira, Anthony H. ;

Gardiner, Chris ;

Sargent, Ian L. ;

Wood, Matthew J. A. ;

Cooper, J. Mark .

NEUROBIOLOGY OF DISEASE, 2011, 42 (03) :360-367

[5] Mitochondrial metabolism in Parkinsons disease impairs quality control autophagy by hampering microtubule-dependent traffic [J].

Arduino, Daniela M. ;

Esteves, A. Raquel ;

Cortes, Luisa ;

Silva, Diana F. ;

Patel, Bindi ;

Grazina, Manuela ;

Swerdlow, Russell H. ;

Oliveira, Catarina R. ;

Cardoso, Sandra M. .

HUMAN MOLECULAR GENETICS, 2012, 21 (21) :4680-4702

[6]

Aviles-Olmos I, 2013, J CLIN INVE IN PRESS

[7] Parkinson's disease, insulin resistance and novel agents of neuroprotection [J].

Aviles-Olmos, Iciar ;

Limousin, Patricia ;

Lees, Andrew ;

Foltynie, Thomas .

BRAIN, 2013, 136 :374-384

[8] AFQ056 Treatment of Levodopa-Induced Dyskinesias: Results of 2 Randomized Controlled Trials [J].

Berg, Daniela ;

Godau, Jana ;

Trenkwalder, Claudia ;

Eggert, Karla ;

Csoti, Iiona ;

Storch, Alexander ;

Huber, Heiko ;

Morelli-Canelo, Monica ;

Stamelou, Maria ;

Ries, Vincent ;

Wolz, Martin ;

Schneider, Christine ;

Di Paolo, Therese ;

Gasparini, Fabrizio ;

Hariry, Sam ;

Vandemeulebroecke, Marc ;

Abi-Saab, Walid ;

Cooke, Katy ;

Johns, Donald ;

Gomez-Mancilla, Baltazar .

MOVEMENT DISORDERS, 2011, 26 (07) :1243-1250

[9] Gene therapy: a viable therapeutic strategy for Parkinson's disease? [J].

Berry, Alexander L. ;

Foltynie, Thomas .

JOURNAL OF NEUROLOGY, 2011, 258 (02) :179-188

[10] Animal Models of Parkinson's Disease: Limits and Relevance to Neuroprotection Studies [J].

Bezard, Erwan ;

Yue, Zhenyu ;

Kirik, Deniz ;

Spillantini, Maria Grazia .

MOVEMENT DISORDERS, 2013, 28 (01) :61-70

← 1 2 3 4 5 6 7 8 →