Structural and stereochemical reassessment of sclerophytin-type diterpenes

被引：20

作者：

Friedrich, D ^{[1
]}

Paquette, LA ^{[1
]}

机构：

[1] Ohio State Univ, Evans Chem Labs, Columbus, OH 43210 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 02期

关键词：

D O I：

10.1021/np0103822

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Marine invertebrates are a rich source of oxygenated diterpenoids.(1-4) Among those isolated from the soft coral Sclerophyturn capitalis are sclerophytins A and B, originally formulated by their discoverers as 1 and 2.(5) The novel structural features of these oxygen-bridged heterocycles and the significant cytotoxic properties of 1 have attracted some defining synthetic work.(6-9) In consideration of the fact that synthetic 3 and 4 both proved to differ significantly from the originally isolated marine metabolites, an extensive N'MR analysis of 2 was undertaken, the results of which identified sclerophytin B to be 6.(10) This thorough investigation also implicated sclerophytin A to be 5 since its simple acetylation leads to 6.(5,7,8).

引用

页码：126 / 130

页数：5

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