Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

被引：128

作者：

Duong, Hien T. T. ^{[1
]}

Kamarudin, Zulkamal M. ^{[1
]}

Erlich, Rafael B. ^{[1
,2
]}

Li, Yang ^{[1
]}

Jones, Mathew W. ^{[1
]}

Kavallaris, Maria ^{[1
,2
]}

Boyer, Cyrille ^{[1
]}

Davis, Thomas P. ^{[1
]}

机构：

[1] Univ New S Wales, Sch Chem Engn, ACN, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Lowy Canc Res Ctr, Childrens Canc Inst Australia, Sydney, NSW 2052, Australia

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 39期

关键词：

IN-VITRO; CANCER CELLS; CISPLATIN; CYTOTOXICITY; CHEMOTHERAPY; APOPTOSIS; DISEASE; DONORS; MICE;

D O I：

10.1039/c2cc37181b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.

引用

页码：4190 / 4192

页数：3

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