Field Strength Dependence of R1 and R2* Relaxivities of Human Whole Blood to ProHance, Vasovist, and Deoxyhemoglobin

被引：117

作者：

Blockley, N. P. ^{[1
]}

Jiang, L. ^{[1
]}

Gardener, A. G. ^{[1
]}

Ludman, C. N. ^{[2
]}

Francis, S. T. ^{[1
]}

Gowland, P. A. ^{[1
]}

机构：

[1] Univ Nottingham, Sch Phys & Astron, Sir Peter Mansfield Magnet Resonance Ctr, Nottingham NG7 2RD, England

[2] Nottingham Univ NHS Trust, Nottingham, England

来源：

MAGNETIC RESONANCE IN MEDICINE | 2008年 / 60卷 / 06期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

contrast agents; blood; relaxivity; BOLD; oxygenation; hematocrit;

D O I：

10.1002/mrm.21792

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

This study has measured the longitudinal and transverse (T-2*) relaxivity curves for Prol-lance (Gadoteridol), Vasovist (Gado-fosveset) and deoxyhemoglobin at 1.5, 3.0, and 7.0 Tesla. The plots of R, versus both contrast agent and deoxyhemoglobin concentration were linear. The plots of R-2* versus deoxyhemoglobin concentration showed a quadratic dependence. R2* versus contrast agent concentration showed a parabolic dependence with a minimum occurring at contrast agent concentrations of approximately 1.5 mM, corresponding to an accessible concentration in vivo. Monte Carlo simulations were performed to support the hypothesis that the minimum results from the susceptibility of the red blood cells being matched to the susceptibility of the plasma. Relaxivity values (s(-1) mM(-1)) for R-2* and R, for all agents and all three field strengths are given. Magn Reson Med 60:1313-1320, 2008. (C) 2008 Wiley-Liss, Inc.

引用

页码：1313 / 1320

页数：8

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