Chromosomal localization of 13 candidate genes for human obesity in the pig genome

被引：21
作者：
Nowacka-Woszuk, Joanna [1 ]
Szczerbal, Izabela [1 ]
Fijak-Nowak, Honorata [1 ]
Switonski, Marek [1 ]
机构：
[1] Poznan Univ Life Sci, Dept Anim Breeding & Genet, PL-60637 Poznan, Poland
来源：
JOURNAL OF APPLIED GENETICS | 2008年 / 49卷 / 04期
关键词：
ADIPOQ; ADRB1; ADRB2; ADRB3; candidate gene; fatness; GNB3; INSIG2; LIPIN1; NAMPT; NR3C1; obesity; pig; PLIN; QTL; UCP1; UCP2; UCP3;
D O I：
10.1007/BF03195636
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Thirteen candidate genes for human obesity were selected for cytogenetic mapping by FISH in the pig genome. Among them, 6 genes were assigned to chromosomes for the first time (NR3C1, GNB3, ADRB1, ADRB2, ADRB3 and UCP1). Location of the other 7 genes (INSIG2, LIPIN1, PLIN, NAMPT, ADIPOQ, UCP2 and UCP3), earlier mapped by somatic cell hybridization or with the use of a radiation hybrid panel, was verified (INSIG2) or more precisely described. The genes were assigned to the following chromosomes: INSIG2 to SSC15q12, LIPIN1 to SSC3q26, NR3C1 to SSC2q29, PLIN to SSC7q15, GNB3 to SSC5q21, NAMPT to SSC9q23, ADIPOQ to SSC13q41, ADRB1 to SSC14q28, ADRB2 to SSC2q29, ADRB3 to SSC15q13-14, UCP1 to SSC8q21-22, and both UCP2 and UCP3 to SSC9p24. Most of the genes were located within known QTL for pig fatness traits.
引用
收藏
页码：373 / 377
页数：5
相关论文
共 27 条
  • [1] Analysis of CA repeat polymorphisms places three human gene loci on the 8p linkage map
    Bruskiewich, R
    Everson, T
    Ma, L
    Chan, L
    Schertzer, M
    Giacobino, JP
    Muzzin, P
    Wood, S
    [J]. CYTOGENETICS AND CELL GENETICS, 1996, 73 (04): : 331 - 333
  • [2] HUMAN UNCOUPLING PROTEIN GENE - STRUCTURE, COMPARISON WITH RAT GENE, AND ASSIGNMENT TO THE LONG ARM OF CHROMOSOME-4
    CASSARD, AM
    BOUILLAUD, F
    MATTEI, MG
    HENTZ, E
    RAIMBAULT, S
    THOMAS, M
    RICQUIER, D
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1990, 43 (03) : 255 - 264
  • [3] CEPICA S, 2008, 31 C INT SOC AN GEN
  • [4] Clarke IJ, 2008, FRONT HORM RES, V36, P107, DOI 10.1159/000115359
  • [5] CROOJMANS RPM, 2008, 31 C INT SOC AN GEN
  • [6] Obesity and polymorphisms in genes regulating human adipose tissue
    Dahlman, I.
    Arner, P.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2007, 31 (11) : 1629 - 1641
  • [7] Cloning, expression and chromosome localization of porcine adiponectin and adiponectin receptors genes
    Dai, MH
    Xia, T
    Zhang, GD
    Chen, XD
    Gan, L
    Feng, SQ
    Qiu, H
    Peng, Y
    Yang, ZQ
    [J]. DOMESTIC ANIMAL ENDOCRINOLOGY, 2006, 30 (02) : 117 - 125
  • [8] Human and porcine correspondence of chromosome segments using bidirectional chromosome painting
    Goureau, A
    Yerle, M
    Schmitz, A
    Riquet, J
    Milan, D
    Pinton, P
    Frelat, G
    Gellin, J
    [J]. GENOMICS, 1996, 36 (02) : 252 - 262
  • [9] STANDARD KARYOTYPE OF THE DOMESTIC PIG
    GUSTAVSSON, I
    [J]. HEREDITAS, 1988, 109 (02): : 151 - 157
  • [10] Investigation of Lpin1 as a candidate gene for fat deposition in pigs
    He, X. P.
    Xu, X. W.
    Zhao, S. H.
    Fan, B.
    Yu, M.
    Zhu, M. J.
    Li, C. C.
    Peng, Z. Z.
    Liu, B.
    [J]. MOLECULAR BIOLOGY REPORTS, 2009, 36 (05) : 1175 - 1180
123