Breast cancer risk and the BRCA1 interacting protein CTIP

被引：3

作者：

Gorringe, Kylie L. ^{[1
]}

Choong, David Y. H. ^{[1
]}

Lindeman, Geoffrey J. ^{[2
]}

Visvader, Jane E. ^{[2
]}

Campbell, Ian G. ^{[1
]}

机构：

[1] Peter MacCallum Canc Ctr, VBCRC Canc Res Lab, Melbourne, Vic 8006, Australia

[2] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2008年 / 112卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

breast cancer; mutation; polymorphism; genetic association; RBBP8;

D O I：

10.1007/s10549-007-9862-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk. We screened CTIP for germline mutations in 210 probands of breast cancer families including 129 families with no mutations in BRCA1 or BRCA2. No coding variants were detected in CTIP, therefore, it is unlikely to be involved in breast cancer risk.

引用

页码：351 / 352

页数：2

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