Multifunctional nanocarriers and intracellular drug delivery

被引：33

作者：

Sawant, Rupa R. ^{[1
]}

Torchilin, Vladimir P. ^{[1
]}

机构：

[1] Northeastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA

来源：

CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE | 2012年 / 16卷 / 06期

关键词：

Ligand-targeted; Long-circulating; Multimodal imaging; Theranostics; Stimuli-sensitive; Nanocarriers; Intracellular delivery; Cell-penetrating peptide; PH-SENSITIVE LIPOSOMES; IN-VITRO CHARACTERIZATION; TARGETED CANCER-THERAPY; HUMAN TUMOR XENOGRAFT; GENE DELIVERY; SOLID TUMORS; PHARMACEUTICAL NANOCARRIERS; PROLONGED CIRCULATION; MACROMOLECULAR DRUGS; PEGYLATED LIPOSOMES;

D O I：

10.1016/j.cossms.2012.09.001

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Multifunctional nanocarriers for the delivery and targeting of therapeutic and diagnostic agents in cancer therapy have received significantly increased interest in recent years. Several multifunctional nanocarriers engineered from a wide range of materials with consolidation of various functionalities for long circulation, targetability, stimuli-sensitivity, intracellular delivery for therapy and imaging have been shown to be capable of killing the desired target diseased cells with minimal side effects to provide enhanced contrast during imaging for disease location and monitor both the fate of the nanocarrier and treatment in real time. This review highlights recent advances in the design and engineering of multifunctional nanocarriers, along with the importance of intracellular delivery. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：269 / 275

页数：7

共 113 条

[1] The next generation of liposome delivery systems: Recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients [J].

Abra, RM ;

Bankert, RB ;

Chen, F ;

Egilmez, NK ;

Huang, K ;

Saville, R ;

Slater, JL ;

Sugano, M ;

Yokota, SJ .

JOURNAL OF LIPOSOME RESEARCH, 2002, 12 (1-2) :1-3

[2]

Alexiou C, 2000, CANCER RES, V60, P6641

[3] Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging [J].

Bartlett, Derek W. ;

Su, Helen ;

Hildebrandt, Isabel J. ;

Weber, Wolfgang A. ;

Davis, Mark E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) :15549-15554

[4] Synthesis and in vitro efficacy of transferrin conjugates of the anticancer drug chlorambucil [J].

Beyer, U ;

Roth, T ;

Schumacher, P ;

Maier, G ;

Unold, A ;

Frahm, AW ;

Fiebig, HH ;

Unger, C ;

Kratz, F .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (15) :2701-2708

[5] Development of the Novel PEG-PE-Based Polymer for the Reversible Attachment of Specific Ligands to Liposomes: Synthesis and in Vitro Characterization [J].

Biswas, Swati ;

Dodwadkar, Namita S. ;

Sawant, Rupa R. ;

Torchilin, Vladimir P. .

BIOCONJUGATE CHEMISTRY, 2011, 22 (10) :2005-2013

[6] MOLECULAR MECHANISM OF THE LIPID VESICLE LONGEVITY INVIVO [J].

BLUME, G ;

CEVC, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1146 (02) :157-168

[7] Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery [J].

Cheng, Ru ;

Feng, Fang ;

Meng, Fenghua ;

Deng, Chao ;

Feijen, Jan ;

Zhong, Zhiyuan .

JOURNAL OF CONTROLLED RELEASE, 2011, 152 (01) :2-12

[8]

Deepagan VG, 2012, NANOMEDICINE-UK, V7, P507, DOI [10.2217/nnm.11.139, 10.2217/NNM.11.139]

[9] Current status of pH-sensitive liposomes in drug delivery [J].

Drummond, DC ;

Zignani, M ;

Leroux, JC .

PROGRESS IN LIPID RESEARCH, 2000, 39 (05) :409-460

[10]

Fang J, 2003, ADV EXP MED BIOL, V519, P29

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