Multifunctional nanocarriers and intracellular drug delivery

被引：32
作者：
Sawant, Rupa R. [1 ]
Torchilin, Vladimir P. [1 ]
机构：
[1] Northeastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA
来源：
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE | 2012年 / 16卷 / 06期
关键词：
Ligand-targeted; Long-circulating; Multimodal imaging; Theranostics; Stimuli-sensitive; Nanocarriers; Intracellular delivery; Cell-penetrating peptide; PH-SENSITIVE LIPOSOMES; IN-VITRO CHARACTERIZATION; TARGETED CANCER-THERAPY; HUMAN TUMOR XENOGRAFT; GENE DELIVERY; SOLID TUMORS; PHARMACEUTICAL NANOCARRIERS; PROLONGED CIRCULATION; MACROMOLECULAR DRUGS; PEGYLATED LIPOSOMES;
D O I：
10.1016/j.cossms.2012.09.001
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Multifunctional nanocarriers for the delivery and targeting of therapeutic and diagnostic agents in cancer therapy have received significantly increased interest in recent years. Several multifunctional nanocarriers engineered from a wide range of materials with consolidation of various functionalities for long circulation, targetability, stimuli-sensitivity, intracellular delivery for therapy and imaging have been shown to be capable of killing the desired target diseased cells with minimal side effects to provide enhanced contrast during imaging for disease location and monitor both the fate of the nanocarrier and treatment in real time. This review highlights recent advances in the design and engineering of multifunctional nanocarriers, along with the importance of intracellular delivery. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：269 / 275
页数：7
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