Intestinal microbiota is a plastic factor responding to environmental changes

被引：167

作者：

Candela, Marco ^{[1
]}

Biagi, Elena ^{[1
]}

Maccaferri, Simone ^{[1
]}

Turroni, Silvia ^{[1
]}

Brigidi, Patrizia ^{[1
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

来源：

TRENDS IN MICROBIOLOGY | 2012年 / 20卷 / 08期

关键词：

human intestinal microbiota; plasticity; dietary habits; immune system; environment; HUMAN GUT MICROBIOME; IMMUNE-RESPONSES; BODY HABITATS; OBESITY; INFLAMMATION; DIET; DIVERSITY; EVOLUTION; CONSEQUENCES; HOMEOSTASIS;

D O I：

10.1016/j.tim.2012.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Traditionally regarded as stable through the entire lifespan, the intestinal microbiota has now emerged as an extremely plastic entity, capable of being reconfigured in response to different environmental factors. In a mutualistic context, these microbiome fluctuations allow the host to rapidly adjust its metabolic and immunologic performances in response to environmental changes. Several circumstances can disturb this homeostatic equilibrium, inducing the intestinal microbiota to shift from a mutualistic configuration to a disease-associated profile. A mechanistic comprehension of the dynamics involved in this process is needed to deal more rationally with the role of the human intestinal microbiota in health and disease.

引用

页码：385 / 391

页数：7

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