Halogenated Anthraquinones from the Marine-Derived Fungus Aspergillus sp SCSIO F063

被引：68

作者：

Huang, Hongbo ^{[1
]}

Wang, Fazuo ^{[1
]}

Luo, Minghe ^{[1
]}

Chen, Yuchan ^{[2
]}

Song, Yongxiang ^{[1
]}

Zhang, Weimin ^{[2
]}

Zhang, Si ^{[1
]}

Ju, Jianhua ^{[1
]}

机构：

[1] Chinese Acad Sci, S China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Mari, Guangzhou 510301, Guangdong, Peoples R China

[2] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 07期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

NATURAL-PRODUCTS; ACID;

D O I：

10.1021/np3002699

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Metabolomic investigations focusing on the marine-derived fungus Aspergillus sp. SCSIO F063 have unveiled seven new chlorinated anthraquinones (1-7) related to averantin, together with five known analogues (11-15) when the fungus was fermented using sea salt-containing potato dextrose broth. Through the addition of sodium bromide to the broth, two new brominated anthraquinones (8, 9) and one new nonhalogenated anthraquinone (10) were obtained from the fungal mycelia. Their structures were elucidated by extensive spectroscopic analyses including MS and ID and 2D NMR data One metabolite, 6-O-methyl-7-chloroaveratin (2), displayed inhibition activity against three human tumor cell lines, SF 268, MCF-7, and NCI-H460, with IC50 values of 7.11, 6.64, and 7.42 mu M, respectively.

引用

页码：1346 / 1352

页数：7

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