Psychiatric Morbidity is Linked to Problem Drinking in Midlife Among Alcohol-Dependent Men: A Co-Twin Control Study

被引:8
作者
Blonigen, Daniel M. [1 ]
Burroughs, Thomas [2 ]
Haber, Jon Randolph [3 ]
Jacob, Theodore [3 ]
机构
[1] Vet Affairs Palo Alto Hlth Care Syst, Ctr Hlth Care Evaluat, Menlo Pk, CA 94025 USA
[2] Palo Alto Univ, Palo Alto, CA USA
[3] Vet Affairs Palo Alto Hlth Care Syst, Family Res Ctr, Menlo Pk, CA 94025 USA
关键词
VIETNAM COMBAT VETERANS; DRUG-USE; USE DISORDERS; SUBSTANCE; ADOLESCENCE; PERSONALITY; HISTORY; HEALTH; ABUSE/DEPENDENCE; TRAJECTORIES;
D O I
10.15288/jsad.2013.74.136
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Objective: Prior research on predictors of problem drinking has been limited because of an inability to attribute an unambiguous environmental explanation to observed findings. Using a prospective co-twin control design, we examined the extent to which a history of psychiatric symptoms exerts an environmental influence on problem drinking in midlife that is unconfounded by genetic underpinnings. Method: Participants were 367 complete male twin pairs (208 monozygotic, 159 dizygotic) from the Vietnam Era Twin Registry who were assessed in midlife as part of the Family Twin Study (M-age = 51.4 years, SD = 2.8). Twin pairs who were concordant for a lifetime diagnosis of an alcohol use disorder (AUD) in 1992 were selected for participation and were reinterviewed in 2001 to measure symptoms of AUD (i.e., problem drinking) since the prior assessment (past 10 years). Results: Within-pair differences in lifetime symptom counts of several psychiatric disorders measured in 1992 (i.e., major depression, dysthymia, generalized anxiety disorder, panic disorder, antisocial personality, mania, and posttraumatic stress disorder) were significantly associated with within-pair differences in AUD symptoms in the subsequent 10 years. Conclusions: A history of psychiatric problems, particularly one marked by internalizing symptoms, appears to be linked to problem drinking in midlife above and beyond the confounding influence of genetic effects and underscores the potential value of integrated interventions for comorbidity to address problem drinking among individuals during this period of the life course. (J. Stud. Alcohol Drugs, 74, 136-140, 2013)
引用
收藏
页码:136 / 140
页数:5
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