Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis

被引：17

作者：

Peixoto, Fabio ^{[1
]}

Camargos, Aroldo ^{[1
]}

Duarte, Geraldo ^{[2
]}

Linhares, Iara ^{[3
]}

Bahamondes, Luis ^{[4
]}

Petracco, Alvaro ^{[5
]}

机构：

[1] Univ Fed Minas Gerais, Lab Human Reprod, Teaching Hosp, Minas Gerais, Brazil

[2] Univ Sao Paulo, Dept Gynecol & Obstet, Ribeirao Preto Sch Med, BR-05508 Sao Paulo, Brazil

[3] Univ Sao Paulo, Dept Gynecol, Sch Med, BR-05508 Sao Paulo, Brazil

[4] Univ Estadual Campinas, Dept Obstet & Gynecol, Campinas, SP, Brazil

[5] Pontifical Catholic Univ, Dept Gynecol & Obstet, Rio Grande Do Sul, Brazil

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2008年 / 102卷 / 03期

关键词：

bacterial vaginosis; metronidazole; miconazole; trichomonal vaginitis; vulvovaginal candidiasis;

D O I：

10.1016/j.ijgo.2008.04.014

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis. Methods: Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment. Results: Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated. Conclusion: Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：287 / 292

页数：6

共 26 条

[11] DIAGNOSTIC MICROBIOLOGY OF BACTERIAL VAGINOSIS
HILLIER, SL
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (02) : 455 - 459
[12] Bacterial vaginosis: Review of treatment options and potential clinical indications for therapy
Joesoef, MR
Schmid, GP
Hillier, SL
[J]. CLINICAL INFECTIOUS DISEASES, 1999, 28 : S57 - S65
[13] EPIDEMIOLOGY OF VAGINITIS
KENT, HL
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1991, 165 (04) : 1168 - 1176
[14] Treatment of vaginitis
Kukner, S
Ergin, T
Cicek, N
Ugur, M
Yesilyurt, H
Gokmen, O
[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 1996, 52 (01) : 43 - 47
[15] Predictive value of the clinical diagnosis of lower genital tract infection in women
Landers, DV
Wiesenfeld, HC
Heine, RP
Krohn, MA
Hillier, SL
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2004, 190 (04) : 1004 - 1009
[16] ABC of sexually transmitted infections - Vaginal discharge - causes, diagnosis, and treatment
Mitchell, H
[J]. BRITISH MEDICAL JOURNAL, 2004, 328 (7451): : 1306 - 1308
[17] NEOTRAN(R) - A NEW DOUBLE-ACTIVE PESSARY FOR THE TREATMENT OF VAGINITIS
MORTON, O
[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1993, 21 (01) : 36 - 46
[18] O'Grady N. P., 2002, Morbidity Mortality Wkly. Rep, V51, P1
[19] Owen MK, 2004, AM FAM PHYSICIAN, V70, P2125
[20] Efficacy of 7-day treatment with metronidazole plus miconazole (Neo-Penotran®) -: a triple-active pessary for the treatment of single and mixed vaginal infections
Özyurt, E
Toykuliyeva, MB
Danilyans, IL
Morton, O
Baktir, G
[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2001, 74 (01) : 35 - 43

← 1 2 3 →