Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis

被引：17
作者：
Peixoto, Fabio [1 ]
Camargos, Aroldo [1 ]
Duarte, Geraldo [2 ]
Linhares, Iara [3 ]
Bahamondes, Luis [4 ]
Petracco, Alvaro [5 ]
机构：
[1] Univ Fed Minas Gerais, Lab Human Reprod, Teaching Hosp, Minas Gerais, Brazil
[2] Univ Sao Paulo, Dept Gynecol & Obstet, Ribeirao Preto Sch Med, BR-05508 Sao Paulo, Brazil
[3] Univ Sao Paulo, Dept Gynecol, Sch Med, BR-05508 Sao Paulo, Brazil
[4] Univ Estadual Campinas, Dept Obstet & Gynecol, Campinas, SP, Brazil
[5] Pontifical Catholic Univ, Dept Gynecol & Obstet, Rio Grande Do Sul, Brazil
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2008年 / 102卷 / 03期
关键词：
bacterial vaginosis; metronidazole; miconazole; trichomonal vaginitis; vulvovaginal candidiasis;
D O I：
10.1016/j.ijgo.2008.04.014
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis. Methods: Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment. Results: Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated. Conclusion: Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：287 / 292
页数：6
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