Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe

被引：83
作者：
Wang, Rongchen [1 ,2 ]
Dong, Kaikai [3 ]
Xu, Ge [1 ,2 ]
Shi, Ben [1 ,2 ]
Zhu, Tianli [1 ,2 ]
Shi, Ping [3 ]
Guo, Zhiqian [1 ,2 ]
Zhu, Wei-Hong [1 ,2 ]
Zhao, Chunchang [1 ,2 ]
机构：
[1] East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China
[3] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
来源：
CHEMICAL SCIENCE | 2019年 / 10卷 / 09期
基金：
美国国家科学基金会;
关键词：
FLUORESCENCE-ENHANCED PROBE; SINGLET OXYGEN GENERATION; TARGETED CANCER-THERAPY; LIGHT-UP PROBE; IN-VIVO; PHOTOSENSITIZER; NANOPARTICLES; PRODRUG; APOPTOSIS; TRACKING;
D O I：
10.1039/c8sc04854a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Development of theranostic probes that can be used to identify tumors and direct the on-demand drug administration to cancers is ongoing but remains challenging. Herein, we report a theranostic platform composed of a H2S-activated imaging probe and a light-sensitive drug. The designed probe affords advantages of H2S-activated NIR emission light- up and efficient O-1(2) generation, enabling the selective visualization of H2S-rich cancers and the subsequent imaging-directed on-demand light exposure to the detected cancers while leaving normal tissues untouched. Such controllable administration of photodynamic anticancer therapy maximizes the therapeutic efficiency and minimizes side effects. This work should facilitate significant advances toward precise diagnosis and treatment of cancer.
引用
收藏
页码：2785 / 2790
页数：6
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