The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review

被引：31
作者：
Zhang, Sheng [1 ]
Xu, Xiang Shang [1 ]
Yang, Jie Xi [1 ]
Guo, Jian Hui [1 ]
Chao, Teng Fei [2 ]
Tong, YiXin [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastrointestinal Surg, Tongji Med Coll, 1095 Jie Fang Ave, Wuhan 430072, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, Tongji Med Coll, Wuhan, Hubei, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2018年 / 11卷
基金：
中国国家自然科学基金;
关键词：
Gas6/Axl; prognosis; solid tumor; biomarker; meta-analysis; overall survival; disease-free survival; RECEPTOR TYROSINE KINASE; ARREST-SPECIFIC GENE-6; BREAST-CANCER; GROWTH-ARREST; AXL KINASE; EXPRESSION; INVASION; TARGET; METASTASIS; ACTIVATION;
D O I：
10.2147/OTT.S150952
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background:Axl is a receptor tyrosine kinase that is involved in many pathological conditions and carcinogenesis. Gas6 is the major ligand of Axl. Activation of Gas6/Axl pathway is essential for cancer development. However, its prognostic significance in solid tumors remains unclear. Therefore, we performed this meta-analysis to elucidate the prognostic impact of Axl. Methods:Published studies on Axl or Gas6 expression and overall survival (OS) and/or disease-free survival (DFS) were searched from databases. The outcome measurement is hazard ratio (HR) for OS or DFS related to Axl/Gas6 expression. Meta-analysis was performed using RevMan. The pooled HR was calculated by fixed-/random-effect models. Results:A total of 3,344 patients from 25 studies were included. The results of meta-analysis showed that Axl overexpression was correlated with shorter OS (HR:2.03, P < 0.0001) and DFS (HR:1.85, P < 0.0001). In subgroup analysis, Axl expression was significantly correlated with poor prognosis in hepatocellular, esophageal and lung cancer. Axl expression was associated with differentiation grade, TNM stage, lymph node and distant metastasis. Conclusion:These results suggest that Axl overexpression is correlated with poor prognosis in solid tumors. This correlation varies among different types of cancers. More studies are needed to further investigate the prognostic value of Axl.
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页码：509 / 519
页数：11
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