Beyond Candida albicans: Mechanisms of immunity to non-albicans Candida species

被引：38

作者：

Whibley, Natasha ^{[1
]}

Gaffen, Sarah L. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Dept Med, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA

[2] Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA

来源：

CYTOKINE | 2015年 / 76卷 / 01期

关键词：

Candida albicans; Non-albicans species; Fungal immunity; INNATE LYMPHOID-CELLS; CATIONIC ANTIMICROBIAL PEPTIDES; PATTERN-RECOGNITION RECEPTOR; HOST-DEFENSE; MEDICALLY IMPORTANT; CYTOKINE PRODUCTION; TH17; CELLS; OPPORTUNISTIC INFECTIONS; ADJUNCTIVE IMMUNOTHERAPY; INTRACELLULAR SURVIVAL;

D O I：

10.1016/j.cyto.2015.07.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fungal genus Candida encompasses numerous species that inhabit a variety of hosts, either as commensal microbes and/or pathogens. Candida species are a major cause of fungal infections, yet to date there are no vaccines against Candida or indeed any other fungal pathogen. Our knowledge of immunity to Candida mainly comes from studies on Candida albicans, the most frequent species associated with disease. However, non-albicans Candida (NAC) species also cause disease and their prevalence is increasing. Although research into immunity to NAC species is still at an early stage, it is becoming apparent that immunity to C. albicans differs in important ways from non-albicans species, with important implications for treatment, therapy and predicted demographic susceptibility. This review will discuss the current understanding of immunity to NAC species in the context of immunity to C. albicans, and highlight as-yet unanswered questions. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：42 / 52

页数：11

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