An endophytic Taxol-producing fungus BT2 isolated from Taxus chinensis var. mairei

被引：0
作者：
Guo, BH
Wang, YC
Zhou, XW
Hu, K
Tan, F
Miao, ZQ
Tang, KX [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Fudan SJTU Nottingham Plant Biotechnol R&D Ctr, Shanghai Key Lab Agrobiotechnol, Plant Biotechnol Res Ctr,Sch Agr & Biol, Shanghai 200030, Peoples R China
[2] SW Normal Univ, Sch Life Sci & Technol, Chongqing 400715, Peoples R China
[3] Fudan Univ, Fudan SJTU Nottingham Plant Biotechnol R&D Ctr, State Key Lab Genet Engn, Sch Life Sci,Morgan Tan Int Ctr Life Sci, Shanghai 200433, Peoples R China
来源：
AFRICAN JOURNAL OF BIOTECHNOLOGY | 2006年 / 5卷 / 10期
关键词：
baccatin III; endophytic fungus; Taxol; Taxus chinensis var. mairei;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
BT2, a newly isolated endophytic fungus from Taxus chinensis var. mairei, was observed to produce Taxol. Besides Taxol, a potent anticancer drug, BT2 could also yield taxane baccatin III, which was an important intermediate for Taxol and semi-synthesis of Taxol in industry. The isolation of such a fungus may provide a promising alterative approach to produce Taxol, and BT2 can serve as a potential material for fungus engineering to improve Taxol production.
引用
收藏
页码：875 / 877
页数：3
相关论文
共 8 条
  • [1] DENG SW, 1963, CHINESE FUNGI, P757
  • [2] PACLITAXEL (TAXOL)
    KOHLER, DR
    GOLDSPIEL, BR
    [J]. PHARMACOTHERAPY, 1994, 14 (01): : 3 - 34
  • [3] Endophytic taxol-producing fungi from bald cypress, Taxodium distichum
    Li, JY
    Strobel, G
    Sidhu, R
    Hess, WM
    Ford, EJ
    [J]. MICROBIOLOGY-UK, 1996, 142 : 2223 - 2226
  • [4] TAXOL AND TAXANE PRODUCTION BY TAXOMYCES-ANDREANAE, AN ENDOPHYTIC FUNGUS OF PACIFIC YEW
    STIERLE, A
    STROBEL, G
    STIERLE, D
    [J]. SCIENCE, 1993, 260 (5105) : 214 - 216
  • [5] Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana
    Strobel, G
    Yang, XS
    Sears, J
    Kramer, R
    Sidhu, RS
    Hess, WM
    [J]. MICROBIOLOGY-UK, 1996, 142 : 435 - 440
  • [6] Taxol from Tubercularia sp strain TF5, an endophytic fungus of Taxus mairei
    Wang, JF
    Li, GL
    Lu, HY
    Zheng, ZH
    Huang, XJ
    Su, WJ
    [J]. FEMS MICROBIOLOGY LETTERS, 2000, 193 (02) : 249 - 253
  • [7] PLANT ANTITUMOR AGENTS .6. ISOLATION AND STRUCTURE OF TAXOL, A NOVEL ANTILEUKEMIC AND ANTITUMOR AGENT FROM TAXUS-BREVIFOLIA
    WANI, MC
    TAYLOR, HL
    WALL, ME
    COGGON, P
    MCPHAIL, AT
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (09) : 2325 - &
  • [8] WEI JC, 1979, HDB FUNGAL IDENTIFIC, P645
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