Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy

被引：10
作者：
Taha, Ameer Y. [1 ]
Ciobanu, Flaviu A.
Saxena, Anjali
Burnham, W. McIntyre
机构：
[1] Univ Toronto, Fac Med, Dept Pharmacol & Toxicol, Toronto, ON M5S 1A8, Canada
来源：
EPILEPSY & BEHAVIOR | 2009年 / 14卷 / 01期
关键词：
Cardiac arrest; Arrhythmias; Ischemia; Omega-3 polyunsaturated fatty acids; Docosahexaenoic acid; Sudden unexpected death in epilepsy; POLYUNSATURATED FATTY-ACIDS; ANTIEPILEPTIC DRUG DEVELOPMENT; RISK-FACTORS; LONG-CHAIN; PRESCRIPTION OMEGA-3-FATTY-ACIDS; INSULIN SENSITIVITY; REFRACTORY EPILEPSY; ECG ABNORMALITIES; RANDOMIZED-TRIAL; TRANSGENIC MICE;
D O I：
10.1016/j.yebeh.2008.10.012
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
People with epilepsy may have abnormal cardiac function. This has been linked to a greater incidence of sudden unexpected death in epilepsy (SUDEP). In the present review, we assess the evidence linking cardiac failure to SUDEP, and propose the use of the maximal pentylenetetrazol seizure test to model SUDEP in animals to identify causal links between cardiac failure and SUDEP. We also discuss recent claims on the use of omega-3 polyunsaturated fatty acids to reduce the incidence of SUDEP because of their cardio-protective and anticonvulsant effects. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：27 / 31
页数：5
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