pH-Responsive nanodrug encapsulated by tannic acid complex for controlled drug delivery

被引：56

作者：

Huang, Huan ^{[1
]}

Li, Ping ^{[1
]}

Liu, Changliang ^{[1
]}

Ma, Huailei ^{[1
]}

Huang, He ^{[1
]}

Lin, Yuchen ^{[1
]}

Wang, Chen ^{[1
]}

Yang, Yanlian ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Standardizat & Measurement Nanotechnol, Key Lab Biol Effects Nanomat & Nanosafety, Ctr Excellence Nanosci,Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

来源：

RSC ADVANCES | 2017年 / 7卷 / 05期

基金：

中国国家自然科学基金;

关键词：

NANOPARTICLES; CAPSULES; PARTICLES; FILMS;

D O I：

10.1039/c6ra26936b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile method for encapsulation of insoluble drugs has been developed based on the metal ion/polyphenol complexation and aerosol spraying process. The encapsulated paclitaxel nanodrug (PTX-C) is well-controlled in morphology and pH-responsive. In vivo and in vitro experiments demonstrated the enhanced anti-tumour activity of PTX-C. This study may pave the way for the fabrication of low cost, high efficiency drug delivery systems for cancer therapies.

引用

页码：2829 / 2835

页数：7

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