Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target

被引：1449

作者：

Peyrin-Biroulet, L. ^{[1
,2
]}

Sandborn, W. ^{[3
]}

Sands, B. E. ^{[4
]}

Reinisch, W. ^{[5
,6
]}

Bemelman, W. ^{[7
]}

Bryant, R. V. ^{[8
]}

D'Haens, G. ^{[9
]}

Dotan, I. ^{[10
]}

Dubinsky, M. ^{[11
]}

Feagan, B. ^{[12
]}

Fiorino, G. ^{[13
]}

Gearry, R. ^{[14
]}

Krishnareddy, S. ^{[15
]}

Lakatos, P. L. ^{[16
]}

Loftus, E. V., Jr. ^{[17
]}

Marteau, P. ^{[18
,19
]}

Munkholm, P. ^{[20
]}

Murdoch, T. B. ^{[21
]}

Ordas, I. ^{[22
]}

Panaccione, R. ^{[23
]}

Riddell, R. H. ^{[24
]}

Ruel, J. ^{[25
]}

Rubin, D. T. ^{[26
]}

Samaan, M. ^{[9
]}

Siegel, C. A. ^{[27
]}

Silverberg, M. S. ^{[28
]}

Stoker, J. ^{[29
]}

Schreiber, S. ^{[30
]}

Travis, S. ^{[31
]}

Van Assche, G. ^{[32
,33
]}

Danese, S. ^{[13
]}

Panes, J. ^{[22
]}

Bouguen, G. ^{[34
,35
,36
]}

O'Donnell, S. ^{[28
]}

Pariente, B. ^{[37
]}

Winer, S. ^{[38
]}

Hanauer, S. ^{[39
]}

Colombel, J. -F. ^{[4
]}

机构：

[1] Univ Lorraine, Univ Hosp Nancy, INSERM U954, Houdemont, France

[2] Univ Lorraine, Univ Hosp Nancy, Dept Hepatogastroenterol, Houdemont, France

[3] Univ Calif San Diego, Div Gastroenterol, La Jolla, CA 92093 USA

[4] Icahn Sch Med Mt Sinai, Henry D Janowitz Div Gastroenterol, New York, NY 10029 USA

[5] McMaster Univ, Hamilton, ON, Canada

[6] Med Univ Vienna, Vienna, Austria

[7] Univ Amsterdam, Acad Med Ctr, Dept Surg, NL-1105 AZ Amsterdam, Netherlands

[8] John Radcliffe Hosp, Translat Gastroenterol Unit, Oxford OX3 9DU, England

[9] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands

[10] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Inflammatory Bowel Dis Ctr,Dept Gastroenterol & L, IL-69978 Tel Aviv, Israel

[11] Icahn Sch Med Mt Sinai, Div Pediat Gastroenterol & Hepatol, New York, NY 10029 USA

[12] Univ Western Ontario, London, ON, Canada

[13] Humanitas Res Hosp, Dept Gastroenterol, Inflammatory Bowel Dis Ctr, Milan, Italy

[14] Univ Otago, Dept Med, Christchurch, New Zealand

[15] Columbia Univ, Div Digest & Liver Dis, New York, NY USA

[16] Semmelweis Univ, Dept Med 1, H-1085 Budapest, Hungary

[17] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA

[18] Hop Lariboisiere Medicosurg, AP HP, Dept Digest Dis, Paris, France

[19] Univ Paris 07, Paris, France

[20] Univ Copenhagen, North Zealand Hosp, Copenhagen, Denmark

[21] Univ Toronto, Mt Sinai Hosp, Inflammatory Bowel Dis Grp, Toronto, ON M5G 1X5, Canada

[22] Hosp Clin Barcelona, IDIBAPS, CIBEREHD, Dept Gastroenterol, Barcelona, Spain

[23] Univ Calgary, Inflammatory Bowel Dis Clin, Calgary, AB, Canada

[24] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

[25] CHU Sherbrooke, Div Gastroenterol, Sherbrooke, PQ J1H 5N4, Canada

[26] Univ Chicago Med, Sect Gastroenterol Hepatol & Nutr, Chicago, IL USA

[27] Dartmouth Hitchcock Inflammatory Bowel Dis Ctr, Hanover, NH USA

[28] Univ Toronto, Mt Sinai Hosp, Div Gastroenterol, Zane Cohen Ctr Digest Dis, Toronto, ON M5G 1X5, Canada

[29] Univ Amsterdam, Acad Med Ctr, Dept Radiol, NL-1105 AZ Amsterdam, Netherlands

[30] Univ Kiel, Univ Hosp Schleswig Holstein, Dept Gen Internal Med, Kiel, Germany

[31] John Radcliffe Hosp, Translat Gastroenterol Unit, Oxford OX3 9DU, England

[32] Katholieke Univ Leuven, Div Gastroenterol, Leuven, Belgium

[33] Univ Toronto, Toronto, ON, Canada

[34] CHU Pontchaillou, Serv Malad Appareil Digestif, Rennes, France

[35] CHU Pontchaillou, INSERM U991, Rennes, France

[36] Univ Rennes 1, Rennes, France

[37] Univ Lille Nord France, Claude Huriez Hosp, Dept Hepatogastroenterol, Lille, France

[38] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[39] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2015年 / 110卷 / 09期

关键词：

QUALITY-OF-LIFE; C-REACTIVE PROTEIN; ACTIVE ULCERATIVE-COLITIS; RANDOMIZED CONTROLLED-TRIAL; COMPUTED-TOMOGRAPHY ENTEROGRAPHY; PATIENT-REPORTED OUTCOMES; EVIDENCE-BASED CONSENSUS; NECROSIS-FACTOR-ALPHA; FORM HEALTH SURVEY; POST-HOC ANALYSIS;

D O I：

10.1038/ajg.2015.233

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

OBJECTIVES: The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) program was initiated by the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD). It examined potential treatment targets for inflammatory bowel disease (IBD) to be used for a "treat-to-target" clinical management strategy using an evidence-based expert consensus process. METHODS: A Steering Committee of 28 IBD specialists developed recommendations based on a systematic literature review and expert opinion. Consensus was gained if >= 75% of participants scored the recommendation as 7-10 on a 10-point rating scale (where 10=agree completely). RESULTS: The group agreed upon 12 recommendations for ulcerative colitis (UC) and Crohn's disease (CD). The agreed target for UC was clinical/patient-reported outcome (PRO) remission (defined as resolution of rectal bleeding and diarrhea/altered bowel habit) and endoscopic remission (defined as a Mayo endoscopic subscore of 0-1). Histological remission was considered as an adjunctive goal. Clinical/PRO remission was also agreed upon as a target for CD and defined as resolution of abdominal pain and diarrhea/altered bowel habit; and endoscopic remission, defined as resolution of ulceration at ileocolonoscopy, or resolution of findings of inflammation on cross-sectional imaging in patients who cannot be adequately assessed with ileocolonoscopy. Biomarker remission (normal C-reactive protein (CRP) and calprotectin) was considered as an adjunctive target. CONCLUSIONS: Evidence-and consensus-based recommendations for selecting the goals for treat-to-target strategies in patients with IBD are made available. Prospective studies are needed to determine how these targets will change disease course and patients' quality of life.

引用

页码：1324 / 1338

页数：15

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