Issues in implementing prenatal screening for cystic fibrosis: Results of a working conference

被引：0

作者：

Haddow, JE

Bradley, LA

Palomaki, GE

Doherty, RA

Bernhardt, BA

Brock, DJH

Cheuvront, B

Cunningham, GC

Donnenfeld, AE

Erickson, JL

Erlich, HA

Ferrie, RM

FitzSimmons, SC

Greene, MF

Grody, WW

Haddow, PK

Harris, H

Holmes, LB

Howell, RR

Katz, M

Klinger, KW

Kloza, EM

LeFevre, ML

Little, S

Loeben, G

McGovern, M

Pyeritz, RE

Rowley, PT

Saiki, RK

Short, MP

Tabone, J

Wald, NJ

Wilker, NL

Witt, DR

机构：

[1] Fdn Blood Res, Scarborough, ME 04070 USA

[2] Johns Hopkins Sch Med, Baltimore, MD USA

[3] Univ Edinburgh, Edinburgh, Midlothian, Scotland

[4] Univ N Carolina, Chapel Hill, NC USA

[5] Calif Dept Hlth, Berkeley, CA USA

[6] Penn Hosp, Philadelphia, PA 19107 USA

[7] Roche Mol Syst, Alameda, CA USA

[8] Zeneca Diagnost, Northwich, Cheshire, England

[9] Cyst Fibrosis Fdn, Bethesda, MD USA

[10] Vincent Mem Obstet Assoc, Boston, MA USA

[11] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA

[12] Cent Manchester Hlth Care Trust, Manchester, Lancs, England

[13] Massachusetts Gen Hosp, Boston, MA 02114 USA

[14] Univ Miami, Sch Med, Miami, FL USA

[15] March Dimes Birth Defects Fdn, White Plains, NY USA

[16] Genzyme, Framingham, MA USA

[17] Univ Missouri, Columbia, MO USA

[18] Univ Penn, Philadelphia, PA 19104 USA

[19] Mt Sinai Sch Med, New York, NY USA

[20] Allegheny Univ Hlth Sci, Pittsburgh, PA USA

[21] Univ Rochester, Sch Med, Rochester, NY USA

[22] Univ Chicago, Chicago, IL 60637 USA

[23] Rapigene Inc, Bothell, WA USA

[24] Wolfson Inst Prevent Med, London, England

[25] Alliance Genet Support Grp, Washington, DC USA

[26] Kaiser Permanente, San Jose, CA USA

来源：

GENETICS IN MEDICINE | 1999年 / 1卷 / 04期

关键词：

cystic fibrosis; screening; prenatal; genetic testing;

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: To summarize a conference convened to examine how cystic fibrosis screening might appropriately be introduced into routine prenatal practice. Methods: Participants included experts from various relevant disciplines. Systematic reviews and data from individual trials were presented; issues were identified and discussed. Results: Judged by published criteria, prenatal cystic fibrosis screening is suitable for introduction. Screening can be performed cost-effectively by identifying racial/ethnic groups at sufficient risk and then using either of two models for delivering laboratory services. Validated educational materials exist. Ethical issues are not unique. Conclusions: Once adequate facilities for patient and provider education, testing, counseling, quality control, and monitoring are in place, individual programs can begin prenatal screening for cystic fibrosis.

引用

页码：129 / 135

页数：7

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