Laser excision of oral leukoplakia: Does it affect recurrence and malignant transformation? A systematic review and meta-analysis

被引：39

作者：

Paglioni, Mariana de Pauli ^{[1
]}

Migliorati, Cesar Augusto ^{[2
]}

Pereira Faustino, Isabel Schausltz ^{[1
]}

Linhares Almeida Mariz, Bruno Augusto ^{[1
]}

Oliveira Correa Roza, Ana Luiza ^{[1
]}

Vargas, Pablo Agustin ^{[1
]}

Paes Leme, Adriana Franco ^{[3
]}

Brandao, Thais Bianca ^{[4
]}

Prado Ribeiro, Ana Carolina ^{[4
]}

Lopes, Marcio Ajudarte ^{[1
]}

Santos-Silva, Alan Roger ^{[1
]}

机构：

[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Oral Diag Dept, Av Limeira 901, Piracicaba, SP, Brazil

[2] Univ Florida, Coll Dent, Gainesville, FL USA

[3] Brazilian Biosci Natl Lab, CNPEM, LNBio, Campinas, Brazil

[4] Sao Paulo Canc Inst ICESP, Dent Dept, Sao Paulo, Brazil

来源：

ORAL ONCOLOGY | 2020年 / 109卷

关键词：

Oral leukoplakia; Leukoplakia; Laser surgery; Laser; Recurrence; Prognosis; Treatment outcome; Systematic review; Meta-analysis; CARBON-DIOXIDE LASER; FOLLOW-UP; CO2-LASER SURGERY; DISORDERS; MANAGEMENT; VAPORIZATION; EVAPORATION; OUTCOMES; REMOVAL; LESIONS;

D O I：

10.1016/j.oraloncology.2020.104850

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oral leukoplakia (OL) is a white lesion with high potential of recurrence and malignant transformation. The variable clinical and histopathological features of OL may potentially impact both treatment and prognosis. Current literature shows that post treatment rates of recurrence and malignant transformation vary widely. The use of surgical lasers have been proposed with the objective of improving outcomes. We performed a systematic review and a comprehensive meta-analysis dedicated to pooling the rates of recurrence and malignant transformation of OL lesions treated using the main types of surgical lasers available. Scopus, MEDLINE/PubMed, and Embase were searched electronically. A total of 36 articles ma the inclusion criteria. Selected studies included OL lesions that were treated by evaporation or excision using Nd:YAG laser, Er:YAG laser, CO2 laser, KTP laser, or diode laser. The results of this systematic review and meta-analysis suggest that surgical laser excision of OL may decrease recurrence rates but have no effect on the malignant transformation of OL when compared with conventional treatments.

引用

页数：10

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