Synthesis and herbicidal activity of new pyrazole ketone derivatives

被引：6

作者：

Fu, Qing ^{[1
,2
]}

Kang, Sheng-Jie ^{[1
,2
]}

Zhong, Liang-Kun ^{[1
,2
]}

Chen, Jie ^{[3
]}

Tan, Cheng-Xia ^{[1
]}

Weng, Jian-Quan ^{[1
]}

Xu, Tian-Ming ^{[2
]}

Liu, Xing-Hai ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China

[2] Zhejiang Res Inst Chem Ind, Zhejiang Base Natl Southern Pesticide Res Ctr, Hangzhou, Peoples R China

[3] Zhejiang A&F Univ, Sch Forestry & Biotechnol, Hangzhou, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2020年 / 196卷 / 02期

关键词：

Synthesis; pyrazole derivatives; molecular docking; herbicidal activity; NEMATOCIDAL ACTIVITY; FUNGICIDAL ACTIVITY; TRIKETONE; DOCKING; INHIBITORS; DESIGN; SAR;

D O I：

10.1080/10426507.2020.1828884

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of pyrazole derivatives was designed according to prodrug strategy. These compounds were synthesized via eight steps and their structures were confirmed by(1)H NMR spectroscopy and MS. The preliminary herbicidal bioassay results indicated that the title pyrazole ketone compounds exhibited low herbicidal activity against six weeds at 150 g/ha, which is weaker than that of the commercial HPPD herbicide topramezone. The docking results showed that the binding mode of the key intermediate (3-(2-(2-fluorophenoxy)ethoxy)-2-methyl-4-(methylsulfonyl)phenyl)(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)methanone is the same as the reported inhibitor DAS689 in the complex.

引用

页码：200 / 205

页数：6

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