Behavioural effects of PNU-282987 and stress in an animal model of Alzheimer's disease

被引：10

作者：

Vicens, Paloma ^{[1
,2
,3
]}

Heredia, Luis ^{[1
,2
,3
]}

Torrente, Margarita ^{[1
,2
,3
]}

Domingo, Jose L. ^{[3
]}

机构：

[1] Univ Rovira & Virgili, Dept Psychol, Tarragona, Spain

[2] Univ Rovira & Virgili, Res Ctr Behav Assessment CRAMC, Tarragona, Spain

[3] Univ Rovira & Virgili, Lab Toxicol & Environm Hlth, Sch Med, IISPV, E-43007 Tarragona, Spain

来源：

PSYCHOGERIATRICS | 2017年 / 17卷 / 01期

关键词：

Alzheimer's disease; behaviour; PNU-282987; stress; NICOTINIC ACETYLCHOLINE-RECEPTOR; BETA-AMYLOID PEPTIDE; ELEVATED ZERO-MAZE; MOUSE MODEL; PHARMACOLOGICAL CHARACTERIZATION; CONCURRENT EXPOSURE; AGONIST PNU-282987; RAT HIPPOCAMPUS; ALPHA-7; MICE;

D O I：

10.1111/psyg.12189

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: Cholinergic deficits play an important role in both cognitive and behavioural alterations in Alzheimer's disease. This study was aimed at evaluating the possible therapeutic role of PNU-282987 (PNU), an 7 nicotinic cholinergic receptor agonist, and the possible effects of stress in precipitating the onset of behavioural deficits in animals with susceptibility to Alzheimer's disease. Methods: B6C3-Tg mice with susceptibility to Alzheimer's disease and wild-type mice either with or without restraint stress received 0- or 1-mg/kg PNU. At 12 months old, mice were evaluated for activity levels, anxiety-like levels, and spatial learning and memory. Results: Data did not show the effects of PNU on activity and anxiety-like behaviour. No effect of PNU on acquisition of a spatial learning task was detected, but a reversal of stress effects on retention in the Morris water maze was observed in transgenic mice. Conclusions: Further studies are needed in order to better understand the role of 7 nicotinic cholinergic receptor agonists in motor activity, anxiety, and spatial learning and memory and to develop more accurate pharmacological treatment of psychopathological diseases.

引用

页码：33 / 42

页数：10

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