A cost-effective combination of Rose Bengal and off-the-shelf cationic polystyrene for the photodynamic inactivation of Pseudomonas aeruginosa

被引：14

作者：

Arnau del Valle, Carla ^{[1
]}

Perez-Laguna, Vanesa ^{[2
]}

Munoz Resta, Ignacio ^{[1
]}

Gavara, Raquel ^{[1
]}

Felip-Leon, Carles ^{[1
]}

Miravet, Juan F. ^{[1
]}

Rezusta, Antonio ^{[2
]}

Galindo, Francisco ^{[1
]}

机构：

[1] Univ Jaume 1, Dept Quim Inorgan & Organ, Avda Sos Baynat S-N, Castellon de La Plana 12071, Spain

[2] Hosp Univ Miguel Servet, Dept Microbiol, IIS Aragon, Zaragoza, Spain

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2020年 / 117卷

关键词：

Bactericidal materials; Antimicrobial photodynamic inactivation; Singlet oxygen; Photosensitizers; Rose Bengal; PORPHYRIN PHOTOSENSITIZERS; ANTIBACTERIAL ACTIVITY; IN-VITRO; LIGHT; PHOTOINACTIVATION; NANOPARTICLES; CONJUGATE; BACTERIA; CHITOSAN;

D O I：

10.1016/j.msec.2020.111302

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Two new photoactive materials have been prepared, characterized and tested against Pseudomonas aeruginosa bacteria (planktonic suspension). The synthesis of the polymeric photosensitizers can be made at a multigram scale, in few minutes, starting from inexpensive and readily available materials, such as Rose Bengal (photo-sensitizer) and ion exchange resins Amberlite (R) IRA 900 (macroporous) or IRA 400 (gel-type) as cationic polystyrene supports. The most notable feature of these systems is their notable bactericidal activity in the dark (4-5 log(10) CFU/mL reduction of the population of P. aeruginosa) which becomes enhanced upon irradiation with visible light (to reach a total reduction of 8 log(10) CFU/mL for the macroporous polymer at a fluence of 120 J/cm(2) using green light of 515 nm).

引用

页数：7

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