The effect of curcin from Jatropha curcas on apoptosis of mouse sarcoma-180 cells

被引：12
|
作者：
Zhao, Qi [2 ]
Wang, Wenguo [3 ]
Wang, Yuehua [2 ]
Xu, Ying [1 ]
Chen, Fang [1 ]
机构：
[1] Sichuan Univ, Coll Life Sci, Chengdu 610064, Peoples R China
[2] Chengdu Univ, Fac Biotechnol Ind, Chengdu 610106, Peoples R China
[3] Minist Agr, Biogas Inst, Chengdu 610041, Peoples R China
来源：
FITOTERAPIA | 2012年 / 83卷 / 05期
关键词：
Curcin; Jatropha curcas; Apoptosis; Sarcoma-180; cells; RIBOSOME-INACTIVATING PROTEINS; TOXIN; DEATH;
D O I：
10.1016/j.fitote.2012.03.005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Curcin is a ribosome-inactivating protein expressed in the endosperm of Jotropha curcas. Curcin can inhibit growth of mouse sarcoma-180 cells. At a curcin concentration of 100 mu g/ml, mouse sarcoma-180 cell growth was inhibited by over 40% after seven days of incubation. Acridine orange staining and flow cytometry analysis also showed that the curcin could induce apoptosis of mouse sarcoma-180 cells. These observations provide a possible explanation for the antitumor properties of curcin. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：849 / 852
页数：4
相关论文
共 50 条
  • [1] EFFECT OF GLYCOL MESYLATES ON MOUSE SARCOMA-180
    CARLSON, WW
    MORGAN, CC
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1954, 85 (02): : 211 - 213
  • [2] EFFECT OF PYRIDOXINE DEFICIENCY ON MOUSE SARCOMA-180
    MIHICH, E
    NICHOL, CA
    CANCER RESEARCH, 1959, 19 (03) : 279 - 284
  • [3] CHARACTERIZATION OF ACIDIC ACTIN IN MOUSE SARCOMA-180 CELLS
    UEYAMA, H
    KUROKAWA, K
    SASAKI, I
    UEDA, K
    CELL STRUCTURE AND FUNCTION, 1987, 12 (05) : 463 - 470
  • [4] Antitumor effects of curcin from seeds of Jatropha curcas
    Lin, J
    Yan, F
    Tang, L
    Chen, F
    ACTA PHARMACOLOGICA SINICA, 2003, 24 (03) : 241 - 246
  • [5] TRIAZENES AS INHIBITORS OF MOUSE SARCOMA-180
    CLARKE, DA
    BARCLAY, RK
    STOCK, CC
    RONDESTVEDT, CS
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1955, 90 (02): : 484 - 489
  • [6] An in silico mutagenesis effect on mode of action of curcin, a toxic protein from Jatropha curcas
    Devi, S. Vimala
    Tyagi, Chetna
    Dhyani, S. K.
    Mishra, A. K.
    Kumar, A.
    Handa, A. K.
    INDIAN JOURNAL OF BIOTECHNOLOGY, 2017, 16 (04): : 655 - 662
  • [7] EFFECT OF CAFFEINE ON MACROMOLECULAR-SYNTHESIS IN SARCOMA-180 MOUSE ASCITES-CELLS
    CHAUDHURI, MM
    GHOSH, S
    INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 1982, 20 (06) : 433 - 436
  • [8] A 5' EXORIBONUCLEASE FROM CYTOPLASMIC EXTRACTS OF MOUSE SARCOMA-180 ASCITES-CELLS
    COUTTS, M
    BRAWERMAN, G
    BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1173 (01) : 57 - 62
  • [9] THE RESPONSE OF MOUSE NEURONS TO MOUSE SARCOMA-37 AND SARCOMA-180
    SMALL, JE
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1959, 102 (01): : 26 - 28
  • [10] EFFECTS ON HOST OF GROWTH OF MOUSE SARCOMA-180
    CLARKE, DA
    TIRSCHWELL, BW
    FRIEDMAN, J
    MORALES, FR
    FEDERATION PROCEEDINGS, 1958, 17 (01) : 358 - 358
12345