Immunogenic cell death and DAMPs in cancer therapy

被引：2448

作者：

Krysko, Dmitri V. ^{[1
,2
]}

Garg, Abhishek D. ^{[3
]}

Kaczmarek, Agnieszka ^{[1
,2
]}

Krysko, Olga ^{[4
]}

Agostinis, Patrizia ^{[3
]}

Vandenabeele, Peter ^{[1
,2
]}

机构：

[1] Univ Ghent VIB, VIB, Dept Mol Biomed Res, Mol Signalling & Cell Death Unit, B-9052 Ghent, Zwijnaarde, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, B-9052 Ghent, Belgium

[3] Univ Leuven KU Leuven, Dept Cellular & Mol Med, Cell Death Res & Therapy Unit, B-3000 Louvain, Belgium

[4] MRB, UZ Gent, Ghent Univ Hosp, Upper Airway Res Lab,Dept Otorhinolaryngol, B-9000 Ghent, Belgium

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 12期

关键词：

ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; PATTERN-RECOGNITION RECEPTORS; FIND-ME SIGNAL; PHOTODYNAMIC THERAPY; APOPTOTIC CELLS; CALRETICULIN EXPOSURE; MULTIDRUG-RESISTANCE; GROWTH-FACTOR; PROTEASOME INHIBITOR;

D O I：

10.1038/nrc3380

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent death that did not trigger an immune response, in recent years a new concept of immunogenic cell death (ICD) has emerged. The immunogenic characteristics of ICD are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface-exposed calreticulin (CRT), secreted ATP and released high mobility group protein B1 (HMGB1). Most DAMPs can be recognized by pattern recognition receptors (PRRs). In this Review, we discuss the role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and the effect of therapy-resistant cancer microevolution on ICD.

引用

页码：860 / 875

页数：16

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