Immunogenic cell death and DAMPs in cancer therapy

被引：2448

作者：

Krysko, Dmitri V. ^{[1
,2
]}

Garg, Abhishek D. ^{[3
]}

Kaczmarek, Agnieszka ^{[1
,2
]}

Krysko, Olga ^{[4
]}

Agostinis, Patrizia ^{[3
]}

Vandenabeele, Peter ^{[1
,2
]}

机构：

[1] Univ Ghent VIB, VIB, Dept Mol Biomed Res, Mol Signalling & Cell Death Unit, B-9052 Ghent, Zwijnaarde, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, B-9052 Ghent, Belgium

[3] Univ Leuven KU Leuven, Dept Cellular & Mol Med, Cell Death Res & Therapy Unit, B-3000 Louvain, Belgium

[4] MRB, UZ Gent, Ghent Univ Hosp, Upper Airway Res Lab,Dept Otorhinolaryngol, B-9000 Ghent, Belgium

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 12期

关键词：

ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; PATTERN-RECOGNITION RECEPTORS; FIND-ME SIGNAL; PHOTODYNAMIC THERAPY; APOPTOTIC CELLS; CALRETICULIN EXPOSURE; MULTIDRUG-RESISTANCE; GROWTH-FACTOR; PROTEASOME INHIBITOR;

D O I：

10.1038/nrc3380

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent death that did not trigger an immune response, in recent years a new concept of immunogenic cell death (ICD) has emerged. The immunogenic characteristics of ICD are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface-exposed calreticulin (CRT), secreted ATP and released high mobility group protein B1 (HMGB1). Most DAMPs can be recognized by pattern recognition receptors (PRRs). In this Review, we discuss the role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and the effect of therapy-resistant cancer microevolution on ICD.

引用

页码：860 / 875

页数：16

共 211 条

[1] F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells [J].

Ahrens, Susan ;

Zelenay, Santiago ;

Sancho, David ;

Hanc, Pavel ;

Kjaer, Svend ;

Feest, Christoph ;

Fletcher, Georgina ;

Durkin, Charlotte ;

Postigo, Antonio ;

Skehel, Mark ;

Batista, Facundo ;

Thompson, Barry ;

Way, Michael ;

Sousa, Caetano Reis e ;

Schulz, Oliver .

IMMUNITY, 2012, 36 (04) :635-645

[2] Mutational and expressional analyses of ATG5, an autophagy-related gene, in gastrointestinal cancers [J].

An, Chang Hyeok ;

Kim, Min Sung ;

Yoo, Nam Jin ;

Park, Sang Wook ;

Lee, Sug Hyung .

PATHOLOGY RESEARCH AND PRACTICE, 2011, 207 (07) :433-437

[3] High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes [J].

Andersson, U ;

Wang, HC ;

Palmblad, K ;

Aveberger, AC ;

Bloom, O ;

Erlandsson-Harris, H ;

Janson, A ;

Kokkola, R ;

Zhang, MH ;

Yang, H ;

Tracey, KJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (04) :565-570

[4] The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Criollo, Alfredo ;

Ortiz, Carla ;

Lidereau, Rosette ;

Mariette, Christophe ;

Chaput, Nathalie ;

Mira, Jean-Paul ;

Delaloge, Suzette ;

Andre, Fabrice ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

IMMUNOLOGICAL REVIEWS, 2007, 220 :47-59

[5] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[6] RETRACTED: Antitumor Activity of Gemcitabine and Oxaliplatin Is Augmented by Thymoquinone in Pancreatic Cancer (Retracted article. See vol. 78, pg. 5468, 2018) [J].

Banerjee, Sanjeev ;

Kaseb, Ahmed O. ;

Wang, Zhiwei ;

Kong, Deujan ;

Mohammad, Mussop ;

Padhye, Subhash ;

Sarkar, Fazlul H. ;

Mohammad, Ramzi M. .

CANCER RESEARCH, 2009, 69 (13) :5575-5583

[7] MITOXANTRONE AS A SINGLE AGENT IN PRETREATED METASTATIC BREAST-CANCER - EFFECTS ON LYMPHOCYTE-T SUBSETS AND THEIR RELATION TO CLINICAL-RESPONSE [J].

BARNI, S ;

LISSONI, P ;

PAOLOROSSI, F ;

RESCALDANI, R ;

CRISPINO, S ;

ARCHILL, C ;

CATTANEO, G ;

TANCINI, G .

TUMORI, 1991, 77 (03) :227-231

[8] CD73: a potent suppressor of antitumor immune responses [J].

Beavis, Paul. A. ;

Stagg, John ;

Darcy, Phillip K. ;

Smyth, Mark J. .

TRENDS IN IMMUNOLOGY, 2012, 33 (05) :231-237

[9] The extracellular release of HMGB1 during apoptotic cell death [J].

Bell, Charles W. ;

Jiang, Weiwen ;

Reich, Charles F., III ;

Pisetsky, David S. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2006, 291 (06) :C1318-C1325

[10] The landscape of somatic copy-number alteration across human cancers [J].

Beroukhim, Rameen ;

Mermel, Craig H. ;

Porter, Dale ;

Wei, Guo ;

Raychaudhuri, Soumya ;

Donovan, Jerry ;

Barretina, Jordi ;

Boehm, Jesse S. ;

Dobson, Jennifer ;

Urashima, Mitsuyoshi ;

Mc Henry, Kevin T. ;

Pinchback, Reid M. ;

Ligon, Azra H. ;

Cho, Yoon-Jae ;

Haery, Leila ;

Greulich, Heidi ;

Reich, Michael ;

Winckler, Wendy ;

Lawrence, Michael S. ;

Weir, Barbara A. ;

Tanaka, Kumiko E. ;

Chiang, Derek Y. ;

Bass, Adam J. ;

Loo, Alice ;

Hoffman, Carter ;

Prensner, John ;

Liefeld, Ted ;

Gao, Qing ;

Yecies, Derek ;

Signoretti, Sabina ;

Maher, Elizabeth ;

Kaye, Frederic J. ;

Sasaki, Hidefumi ;

Tepper, Joel E. ;

Fletcher, Jonathan A. ;

Tabernero, Josep ;

Baselga, Jose ;

Tsao, Ming-Sound ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Janne, Pasi A. ;

Daly, Mark J. ;

Nucera, Carmelo ;

Levine, Ross L. ;

Ebert, Benjamin L. ;

Gabriel, Stacey ;

Rustgi, Anil K. ;

Antonescu, Cristina R. ;

Ladanyi, Marc ;

Letai, Anthony .

NATURE, 2010, 463 (7283) :899-905

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