Urinary and circulating levels of the anti-angiogenic isoform of vascular endothelial growth factor-A in patients with chronic kidney disease

被引：6

作者：

Kikuchi, Ryosuke ^{[1
]}

Yasuda, Yoshinari ^{[2
]}

Nakatochi, Masahiro ^{[3
]}

Shibata, Yohei ^{[4
]}

Hara, Toshiaki ^{[1
]}

Suzuki, Atsuo ^{[1
]}

Imaizumi, Takahiro ^{[5
]}

Suzuki, Susumu ^{[4
]}

Ishii, Hideki ^{[4
]}

Takeshita, Kyosuke ^{[4
,6
]}

Matsushita, Tadashi ^{[6
]}

Maruyama, Shoichi ^{[5
]}

Murohara, Toyoaki ^{[4
]}

机构：

[1] Nagoya Univ Hosp, Dept Med Tech, Nagoya, Aichi, Japan

[2] Nagoya Univ, Dept CKD Initiat Nephrol, Grad Sch Med, Nagoya, Aichi, Japan

[3] Nagoya Univ Hosp, Stat Anal Sect, Ctr Adv Med & Clin Res, Nagoya, Aichi, Japan

[4] Nagoya Univ, Dept Cardiol, Grad Sch Med, Nagoya, Aichi, Japan

[5] Nagoya Univ, Dept Nephrol, Grad Sch Med, Nagoya, Aichi, Japan

[6] Nagoya Univ Hosp, Dept Clin Lab, Nagoya, Aichi, Japan

来源：

CLINICA CHIMICA ACTA | 2017年 / 475卷

关键词：

Chronic kidney disease; Glomerular filtration rate; Vascular endothelial growth factor-A(165)b; GLOMERULAR CAPILLARY REPAIR; MESSENGER-RNA; EXPRESSION; VEGF; ASSOCIATION; VEGF(165)B; INFLAMMATION; POPULATION; RECEPTORS; BLOCKADE;

D O I：

10.1016/j.cca.2017.10.014

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Introduction: The protective effects of vascular endothelial growth factor (VEGF)-A(165)b on kidney tissue have been suggested in animal studies. However, the relevance of urinary and circulating VEGF-A(165)b levels in chronic kidney disease patients remains unclear. Therefore, the present study aimed to investigate the urinary and circulating VEGF-A(165)b levels in patients with chronic kidney disease. Methods: This observational study enrolled a total of 92 Japanese patients with chronic kidney disease, who had undergone inulin renal clearance measurements for the accurate assessment of measured GFR. Urinary or circulating total VEGF-A and VEGF-A(165)b levels were measured using enzyme-linked immunosorbent assay. Results: Urinary VEGF-A(165)b levels were significantly lower in G3a, G3b, and G4 + G5 category patients than in G1 + G2 category patients. Correlation analysis found that serum creatinine levels, serum cystatin C levels, eGFRcre, eGFRcys, and mGFR were weakly but significantly correlated with urinary VEGF-A(165)b levels. Additionally, circulating VEGF-A(165)b levels were significantly higher in G4 + G5 category patients than in G1 + G2 category patients. Conclusion: A low urinary VEGF-A(165)b level reflects renal dysfunction in the chronic kidney disease stage, while a high circulating VEGF-A(165)b level cannot be attributed to decreased renal clearance.

引用

页码：102 / 108

页数：7

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