Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells

被引：19

作者：

Huang, Yan ^{[1
]}

Bao, Ting ^{[1
]}

Li, Zhenzhen ^{[1
]}

Ji, Guiyi ^{[1
]}

Zhang, Li ^{[2
]}

机构：

[1] Sichuan Univ, Hlth Management Ctr, West China Hosp, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Lab Pathol, West China Hosp, 37 Guo Xue Xiang Rd, Chengdu 610041, Sichuan, Peoples R China

来源：

ONCOLOGY LETTERS | 2020年 / 20卷 / 02期

基金：

国家重点研发计划;

关键词：

microRNA-200a; non-small cell lung cancer; proliferation; apoptosis; Rhophilin Rho GTPase binding protein 2; EPITHELIAL-MESENCHYMAL TRANSITION; REPRESSORS ZEB1; FAMILY; STATISTICS; EXPRESSION; PROMOTES; TARGETS; MIGRATION; INVASION; PROTEIN;

D O I：

10.3892/ol.2020.11649

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer is the most prevalent type of cancer worldwide and is the leading cause of cancer-associated cases of mortality in the USA and China. Non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases. microRNAs (miRs) serve multiple roles in the pathogenesis of lung cancer. The current study investigated the lower level of miR-200a in tumor tissues compared with healthy tissue. Overexpression of miR-200a inhibited NSCLC cell proliferation and promoted apoptosis. miR-200a was identified to target Rhophilin Rho GTPase binding protein 2 (RHPN2) and higher levels of RHPN2 were observed in tumor tissues compared with adjacent normal tissues. The current study proposes that miR-200a exhibits a tumor suppressive role in NSCLC and suggests that miR-200a could target RHPN2.

引用

页码：1256 / 1262

页数：7

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