Discovery of novel trisubstituted cyclohexane derivatives as potent and bioavailable CCR2 antagonists

被引：0

作者：

Cherney, Robert J. ^{[1
]}

Mo, Ruowei ^{[1
]}

Yang, Michael G. ^{[1
]}

Xiao, Zili ^{[1
]}

Meyer, Dayton T. ^{[1
]}

Zhao, Qihong ^{[1
]}

Mandlekar, Sandhya ^{[1
]}

Lo, Yvonne C. ^{[1
]}

Yang, Gengjie ^{[1
]}

Miller, Persymphonie B. ^{[1
]}

Scherle, Peggy A. ^{[1
]}

Wasserman, Zelda R. ^{[1
]}

Jezak, Heather ^{[1
]}

Solomon, Kimberly A. ^{[1
]}

Tebben, Andrew J. ^{[1
]}

Cvijic, Mary Ellen ^{[1
]}

Barrish, Joel C. ^{[1
]}

Decicco, Carl P. ^{[1
]}

Carter, Percy H. ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Res & Dev, Princeton, NJ 08543 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 245卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

292-MEDI

引用

页数：1

共 50 条

[1] Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists
Cherney, Robert J.
Brogan, John B.
Mo, Ruowei
Lo, Yvonne C.
Yang, Gengjie
Miller, Persymphonie B.
Scherle, Peggy A.
Molino, Bruce F.
Carter, Percy H.
Decicco, Carl P.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (03) : 597 - 601
[2] Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists
Cherney, Robert J.
Moa, Ruowei
Yang, Michael G.
Xiao, Zili
Zhao, Qihong
Mandlekar, Sandhya
Cvijic, Mary Ellen
Charo, Israel F.
Barrish, Joel C.
Decicco, Carl P.
Carter, Percy H.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (07) : 1843 - 1845
[3] Discovery of trisubstituted cyclohexanes as a new class of CCR2 antagonists
Cherney, Robert J.
Mo, Ruowei
Meyer, Dayton T.
Nelson, David J.
Lo, Yvonne C.
Yang, Gengjie
Scherle, Peggy A.
Mandlekar, Sandhya
Wasserman, Zelda R.
Jezak, Heather
Solomon, Kimberly A.
Tebben, Andrew J.
Carter, Percy H.
Decicco, Carl P.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 641 - 641
[4] Discovery of novel monoaryl CCR2 antagonists
Lanter, James C.
Markotan, Thomas P.
Subasinghe, Nalin L.
Lawson, Edward C.
Hou, Cuifen
Opas, Evan
McKenney, Sandra
Crysler, Carl
O'Neill, John
Johnson, Dana
Sui, Zhihua
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
[5] The discovery of novel cyclohexylamide CCR2 antagonists
Lanter, James C.
Markotan, Thomas P.
Zhang, Xuqing
Subasinghe, Nalin
Kang, Fu-An
Hou, Cuifen
Singer, Monica
Opas, Evan
McKenney, Sandra
Crysler, Carl
Johnson, Dana
Molloy, Christopher J.
Sui, Zhihua
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (24) : 7496 - 7501
[6] Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist
Pasternak, Alexander
Goble, Stephen D.
Struthers, Mary
Vicario, Pasquale P.
Ayala, Julia M.
Di Salvo, Jerry
Kilburn, Ruth
Wisniewski, Thomas
DeMartino, Julie A.
Mills, Sander G.
Yang, Lihu
ACS MEDICINAL CHEMISTRY LETTERS, 2010, 1 (01): : 14 - 18
[7] Discovery of potent, orally bioavailable CCR5 antagonists - 2.
Palani, A
Shapiro, S
Josien, H
Bara, T
Clader, J
Greenlee, W
Tagat, J
Steensma, R
McCombie, S
Neustadt, B
Pushpavanam, P
Chan, TM
Evans, A
Blythin, D
Ganguly, A
Piwinski, J
Dan, N
Baroudy, B
Endres, M
Strizki, J
Vantuno, N
Cox, K
Broske, L
Zhang, X
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U5 - U5
[8] Novel, orally bioavailable γ-aminoamide CC chemokine receptor 2 (CCR2) antagonists
Pasternak, Alexander
Marino, Dominick
Vicario, Pasquale P.
Ayala, Julia Marie
Cascierri, Margaret A.
Parsons, William
Mills, Sander G.
MacCoss, Malcolm
Yang, Lihu
JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (16) : 4801 - 4804
[9] Use of a pH-dependent conformational switching mechanism to enable the discovery of potent, selective and orally bioavailable CCR2 antagonists
Yang, Michael
Xiao, Zili
Cherney, Robert
Tebben, Andrew
Batt, Douglas
Brown, Gregory
Chen, Jing
Cvijic, Mary
Dabros, Marta
Duncia, John
Galella, Michael
Gardner, Daniel
Khandelwal, Purnima
Ko, Soo
Malley, Mary
Mo, Ruowei
Pang, Jian
Rose, Anne
Santella, Joseph
Shi, Hong
Srivastava, Anurag
Traeger, Sarah
Vuppugalla, Ragini
Wang, Bei
Xu, Songmei
Zhao, Rulin
Barrish, Joel
Mandlekar, Sandhya
Zhao, Qihong
Carter, Percy
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
[10] Discovery and profile of β-keto-sulfone analogs:: Potent, selective, and novel CCR2 receptor antagonists
Song, Y
Sun, KL
Bratton, L
Unangst, P
Miller, S
Millar, M
Low, J
Gong, H
Heilig, D
Trivedi, BK
ATHEROSCLEROSIS SUPPLEMENTS, 2003, 4 (02) : 65 - 65

← 1 2 3 4 5 →