Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis

被引：11

作者：

Fang, Ling ^{[1
]}

Zheng, Qi ^{[1
]}

Yang, Tao ^{[2
]}

Zhao, Hui ^{[1
]}

Zhang, Qiuxia ^{[1
]}

Li, Kangning ^{[2
]}

Zhou, Li ^{[2
]}

Gong, Haiyang ^{[2
]}

Fan, Yongping ^{[2
]}

Wang, Lei ^{[1
]}

机构：

[1] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China

[2] Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 35期

基金：

中国国家自然科学基金;

关键词：

neural regeneration; traditional Chinese medicine; multiple sclerosis; experimental autoimmune encephalomyelitis; Bushen Yisui Capsule; amyloid precursor protein; microtubule-associated protein 2; grants-supported paper; neuroregeneration; AMYLOID PRECURSOR PROTEIN; MULTIPLE-SCLEROSIS; ANIMAL-MODEL; BRAIN-INJURY; EXPRESSION; INFLAMMATION; PLASTICITY; PATHOLOGY; LESIONS; MAP2;

D O I：

10.3969/j.issn.1673-5374.2013.35.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly called Erhuang Formula) in combination with conventional therapy is an effective prescription for the treatment of multiple sclerosis. However, its effect on axonal injury during early multiple sclerosis remains unclear. In this study, a MOG(35-55)-immunized C57BL/6 mouse model of experimental autoimmune encephalomyelitis was intragastrically administered Bushen Yisui Capsule. The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis. In addition, amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated. Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoimmune encephalomyelitis was mediated by amelioration of axonal damage and promotion of regeneration. But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction.

引用

页码：3306 / 3315

页数：10

共 44 条

[21]

Liu GZ, 2012, MULTIPLE SCLEROSIS

[22]

Liu Jian, 2012, Zhong Xi Yi Jie He Xue Bao, V10, P141, DOI 10.3736/jcim20120204

[23]

[陆正齐 LU Zhengqi], 2008, [中山大学学报. 医学科学版, Journal of Sun Yat-sen University. Medical Sciences], V29, P684

[24] Cerebrospinal Fluid Levels of Soluble Amyloid Precursor Protein and β-Amyloid 42 in Patients with Multiple Sclerosis, Neuromyelitis Optica and Clinically Isolated Syndrome [J].

Mai, W. ;

Hu, X. ;

Lu, Z. ;

Peng, F. ;

Wang, Y. .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2011, 39 (06) :2402-2413

[25] Plasticity of hippocampus following perinatal asphyxia:: Effects on postnatal apoptosis and neurogenesis [J].

Morales, P. ;

Fiedler, J. L. ;

Andres, S. ;

Berrios, C. ;

Huaiquin, P. ;

Bustamante, D. ;

Cardenas, S. ;

Parra, E. ;

Herrera-Marschitz, M. .

JOURNAL OF NEUROSCIENCE RESEARCH, 2008, 86 (12) :2650-2662

[26] IMMATURE AND MATURE VARIANTS OF MAP2 AND TAU PROTEINS AND NEURONAL PLASTICITY [J].

NUNEZ, J .

TRENDS IN NEUROSCIENCES, 1988, 11 (11) :477-479

[27] Multiple Sclerosis: New Insights in Pathogenesis and Novel Therapeutics [J].

Ontaneda, Daniel ;

Hyland, Megan ;

Cohen, Jeffrey A. .

ANNUAL REVIEW OF MEDICINE, VOL 63, 2012, 63 :389-404

[28] Cytoskeletal derangements of cortical neuronal processes three hours after traumatic brain injury in rats: An immunofluorescence study [J].

Posmantur, RM ;

Kampfl, A ;

Liu, SJ ;

Heck, K ;

Taft, WC ;

Clifton, GL ;

Hayes, RL .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (01) :68-80

[29] Axonal Pathology and Loss Precede Demyelination and Accompany Chronic Lesions in a Spontaneously Occurring Animal Model of Multiple Sclerosis [J].

Seehusen, Frauke ;

Baumgaertner, Wolfgang .

BRAIN PATHOLOGY, 2010, 20 (03) :551-559

[30]

SHERRIFF FE, 1994, ACTA NEUROPATHOL, V87, P55

← 1 2 3 4 5 →