Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis

被引：11

作者：

Fang, Ling ^{[1
]}

Zheng, Qi ^{[1
]}

Yang, Tao ^{[2
]}

Zhao, Hui ^{[1
]}

Zhang, Qiuxia ^{[1
]}

Li, Kangning ^{[2
]}

Zhou, Li ^{[2
]}

Gong, Haiyang ^{[2
]}

Fan, Yongping ^{[2
]}

Wang, Lei ^{[1
]}

机构：

[1] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China

[2] Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 35期

基金：

中国国家自然科学基金;

关键词：

neural regeneration; traditional Chinese medicine; multiple sclerosis; experimental autoimmune encephalomyelitis; Bushen Yisui Capsule; amyloid precursor protein; microtubule-associated protein 2; grants-supported paper; neuroregeneration; AMYLOID PRECURSOR PROTEIN; MULTIPLE-SCLEROSIS; ANIMAL-MODEL; BRAIN-INJURY; EXPRESSION; INFLAMMATION; PLASTICITY; PATHOLOGY; LESIONS; MAP2;

D O I：

10.3969/j.issn.1673-5374.2013.35.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly called Erhuang Formula) in combination with conventional therapy is an effective prescription for the treatment of multiple sclerosis. However, its effect on axonal injury during early multiple sclerosis remains unclear. In this study, a MOG(35-55)-immunized C57BL/6 mouse model of experimental autoimmune encephalomyelitis was intragastrically administered Bushen Yisui Capsule. The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis. In addition, amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated. Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoimmune encephalomyelitis was mediated by amelioration of axonal damage and promotion of regeneration. But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction.

引用

页码：3306 / 3315

页数：10

共 44 条

[1] Critical appraisal of animal models of multiple sclerosis [J].

Baker, David ;

Gerritsen, Wouter ;

Rundle, Jon ;

Amor, Sandra .

MULTIPLE SCLEROSIS JOURNAL, 2011, 17 (06) :647-657

[2] INFLAMMATORY REACTION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE) IS ACCOMPANIED BY A MICROGLIAL EXPRESSION OF THE BETA-A4-AMYLOID PRECURSOR PROTEIN (APP) [J].

BANATI, RB ;

GEHRMANN, J ;

LANNESVIEIRA, J ;

WEKERLE, H ;

KREUTZBERG, GW .

GLIA, 1995, 14 (03) :209-215

[3] Increased KPI containing amyloid precursor protein in experimental autoimmune encephalomyelitis brains [J].

Beilin, Orit ;

Karussis, Dimitrios M. ;

Korczyn, Amos D. ;

Gurwitz, David ;

Aronovich, Ramona ;

Mizrachi-Kol, Rachel ;

Chapman, Joab .

NEUROREPORT, 2007, 18 (06) :581-584

[4] Pathogenic MOG-reactive CD8+T cells require MOG-reactive CD4+T cells for sustained CNS inflammation during chronic EAE [J].

Bettini, Maria ;

Rosenthal, Kristen ;

Evavold, Brian D. .

JOURNAL OF NEUROIMMUNOLOGY, 2009, 213 (1-2) :60-68

[5] STAINING OF AMYLOID PRECURSOR PROTEIN TO STUDY AXONAL DAMAGE IN MILD HEAD-INJURY [J].

BLUMBERGS, PC ;

SCOTT, G ;

MANAVIS, J ;

WAINWRIGHT, H ;

SIMPSON, DA ;

MCLEAN, AJ .

LANCET, 1994, 344 (8929) :1055-1056

[6]

Chinese Medical Association Chinese Society of Neurology, 2010, ZHONGHUA SHENJING KE, V43, P516

[7] Glial Amyloid Precursor Protein Expression is Restricted to Astrocytes in an Experimental Toxic Model of Multiple Sclerosis [J].

Clarner, Tim ;

Buschmann, Jan Philipp ;

Beyer, Cordian ;

Kipp, Markus .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2011, 43 (03) :268-274

[8] Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) [J].

Constantinescu, Cris S. ;

Farooqi, Nasr ;

O'Brien, Kate ;

Gran, Bruno .

BRITISH JOURNAL OF PHARMACOLOGY, 2011, 164 (04) :1079-1106

[9] Expression and regulation of matrix metalloproteinase-12 in experimental autoimmune encephalomyelitis and by bone marrow derived macrophages in vitro [J].

DaSliva, Angelika Goncalves ;

Yong, V. Wee .

JOURNAL OF NEUROIMMUNOLOGY, 2008, 199 (1-2) :24-34

[10] Acute focal ischemia-induced alterations in MAP2 immunostaining: Description of temporal changes and utilization as a marker for volumetric assessment of acute brain injury [J].

Dawson, DA ;

Hallenbeck, JM .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (01) :170-174

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